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Гаврилин, М. В.; Fat'yanova, E. A.; Lukashova, L. A.; Kompantseva, E. V.; Ziep, C. V.

doi:10.1023/a:1010371500601

Cited by 3 publications

(2 citation statements)

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“…Ibuprofen shows bad manufacturing behavior; the flow properties are poor and it has a high tendency to stick to the punches [3]. Earlier works on the crystal growth of ibuprofen were mostly by solution growth method [4][5][6][7][8][9] and also the obtained crystals were of small size. Crystallization of bulk crystals, less studied physical and technological properties made the authors carry out this work.…”

Section: Introductionmentioning

confidence: 99%

Growth, spectral and thermal studies of ibuprofen crystals

Ramukutty

Ramachandran

2011

Cryst. Res. Technol.

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Key words ibuprofen, gel growth, FTIR, UV-Vis, TGA/DTA. RS-Ibuprofen was crystallized for the first time in silica gel under suitable pH conditions by reduction of solubility method. The grown crystals were characterized by single crystal X-ray diffraction and density measurement. The functional groups present in the crystal were identified using Fourier transform infrared spectroscopy. Optical bandgap energy of ibuprofen was estimated as 3.19(3) eV from UV-Vis spectrum. Thermogravimetric analysis revealed that ibuprofen is thermally stable upto 102.9 °C and the initial loss of mass was due to evaporation only. Morphological study showed that the growth is prominent along b-axis and the prominent face is {100}.

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Section: Introductionmentioning

confidence: 99%

Growth, spectral and thermal studies of ibuprofen crystals

Ramukutty

Ramachandran

2011

Cryst. Res. Technol.

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“…Ibuprofen is one of the most popular drugs and belongs to class II according to the biopharmaceutical classification system 40 due to its low solubility (0.143 g l −1 under ambient conditions). 41 To increase the solubility of ibuprofen, several methods have been considered: (a) application of an ibuprofen metastable polymorphic form; 42 (b) using its amorphous form; 43,44 (c) selective synthesis of ibuprofen crystals with different habits; 45–47 (d) using the more active dextrorotatory s -enantiomer. 48,49 Application of all these approaches faced practical difficulties.…”

Section: Introductionmentioning

confidence: 99%