99mTc-diethyl-IDA: The extraction efficiency of the liver

Galli, G; Orlando, Paolo; Massari, P.; Bonifazi, N.; Magistrelli, Paolo; Coppola, Roberto

doi:10.1007/bf00253763

Cited by 6 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these factors are mentioned and discussed as follows: 1) We assume no back diffusion of the radio-pharmaceutical between compartments, namely between the hepatic compartment and the blood. This is probably true in normal situations 15 but not the case in certain hepatic diseases 16 .…”

Section: Discussionmentioning

confidence: 93%

A new method for quantification of hepatobiliary scintigraphy using 99mTc—mebrofenin. A comparative study

Lima

Lima²,

Isidoro

et al. 2003

Revista Española de Medicina Nuclear

View full text Add to dashboard Cite

Summary.-A method based upon the application of mathematical techniques of deconvolution on the classical compartmental model for the quantitative study of liver function from hepatobiliary scintigraphy using 99m Tc-mebrofenin data is proposed. The theory in which the method is based upon is presented and a comparison with a published methodology of obtaining the hepatic extraction after scintigraphic sudies has been performed using the results on 36 rats studies obtained with the two methods. A highly significant correlation between the two techniques was verified. The characterisitics of the two methodologies, the proposed one based upon a theoretical approach and the other one on an empirical approximation are discussed. Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency. Resumen.-Se propone un método basado en la aplicación de técnicas matemáticas de deconvolución sobre el modelo compartimental clásico para el estudio cuantitativo de la función hepática con datos de gammagrafía hepatobiliar con 99mTc-mebrofenina. Se presenta la teoría sobre la cual se basa el método y se hace una comparación con una metodología publicada para la obtención de la extracción hepática después de hacer estudios grammagráficos utilizando los resultados de 36 estudios en ratas, obtenidos con los dos métodos. Se comprobó una correlación altamente significativa entre las dos técnicas. Se discuten las características de las dos metodologías, la propuesta basada en un enfoque teórico y la otra en un enfoque empírico. Se comenta el interés y limitaciones de la técnica presentada que puede ser una herramienta útil para la evaluación de la insuficiencia hepática. PALABRAS CLAVES: Gammagrafía hepatobiliar. Análisis de deconvolución. Función hepática. INTRODUCTIONStudies of liver function based on scintigraphic data using compartmental modelling have been tried by several groups [1][2][3][4][5] . Results from these classical models are usually presented as rate constants for the hepatic extraction from the plasma and, in the case of hepatobiliary scintigraphy, also for the hepatic excretion. Other measured parameters are the disappearance half-life (T 1/2 ) and mean of the residence time for the radio-pharmaceutical molecules. The method proposed is based upon the application of mathematical techniques of deconvolution over the classical compartmental model. The quantification of parameters with physiologic meaning, in hepatobiliary scintigraphy may be obtained by using 99m Tc-mebrofenin. After a venous puncture this agent (or any of the last generation 99m Tc-IDA derivatives) is transported in blood mainly loosely bound to albumin. In the space of Disse, 99m Tc-mebrofenin is taken up by the hepatocyte and excreted into the intestine through the bile, without modifications 6 . This radio-pharmaceutical has high specificity for hepatocyte uptake (98 %), rapid blood clearance, fast intra-hepatic transit and no enteric absorption. Sixty minutes aft...

show abstract

Section: Discussionmentioning

confidence: 93%

A new method for quantification of hepatobiliary scintigraphy using 99mTc—mebrofenin. A comparative study

Lima

Lima²,

Isidoro

et al. 2003

Revista Española de Medicina Nuclear

View full text Add to dashboard Cite

show abstract

“…The validity of using TDDU to measure portal blood flow was simultaneously investigated by comparing the results of this technique against an accurate clearance method employing radiolabeled iminodiacetic acid (IDA) compounds. The hepatic extraction efficiency in these compounds is close to 100% in healthy livers [41,42]. Finally, the impact of a physiological increase in portal pressure on the respiratory index was studied.…”

Section: Introductionmentioning

confidence: 99%

Influence of Respiration and Portal Pressure on Transabdominal Duplex Doppler Ultrasound Measurement of Portal Blood Flow: A Porcine Model for Experimental Studies

Chow¹,

Yu²,

Ng³

et al. 2000

Journal of Surgical Research

View full text Add to dashboard Cite

Model identification and estimation of organ-function parameters using radioactive tracers and the impulse-response function

et al. 1985

View full text Add to dashboard Cite

Examination of the input-output events in functioning organs by the use of the impulse-response function (IRF) for a radioactive tracer is gaining more and more ground in nuclear medicine. This study summarizes the development of deconvolution analysis, laying special stress on the 'model-free' approach. System linearity and time invariance are discussed, and means of eliminating noise in IRFs originating from the input and organ-time-activity curves are outlined. Typical IRFs are illustrated by flow diagrams, time-domain curves, and their representation by Laplace transforms. The cases of nondiffusible and diffusible tracers as well as parenchymally extracted and transported substances are discussed. Methods for the derivation of models and for the calculation of physiologically important parameters from the IRFs are suggested.

show abstract

99mTc-diethyl-IDA: The extraction efficiency of the liver

Cited by 6 publications

References 5 publications

A new method for quantification of hepatobiliary scintigraphy using 99mTc—mebrofenin. A comparative study

A new method for quantification of hepatobiliary scintigraphy using 99mTc—mebrofenin. A comparative study

Influence of Respiration and Portal Pressure on Transabdominal Duplex Doppler Ultrasound Measurement of Portal Blood Flow: A Porcine Model for Experimental Studies

Model identification and estimation of organ-function parameters using radioactive tracers and the impulse-response function

Contact Info

Product

Resources

About