99mTc Anti-CD 15 Monoclonal Antibody (LeuTech) Imaging Improves Diagnostic Accuracy and Clinical Management in Patients With Equivocal Presentation of Appendicitis

Review of the pathological results of 2660 appendicectomy specimens

“…They concluded that this method reduced the false rate of laparotomy and shortened the time necessary for clinical observation. Rypins et al 12 studied the diagnostic use of Tc-99m-labeled anti-CD 15 IgM monoclonal antibody and found that the sensitivity was 98% and specificity 84%. Similarly, the use of diagnostic laparoscopy followed by appendicectomy if necessary in fertile female patients was found to reduce the rate of 13 concluded that the negative appendicectomy rate was reduced from 38% to 5% in fertile female patients by the use of laparoscopy and from 8% to 4% in postmenopausal women and in men.…”

Prospective evaluation of diagnostic modalities in suspected acute appendicitis

“…Therefore ultrasonography, even in an emergency setting and carried out by less-experienced examiners, seems to be the most-valuable single diagnostic tool in suspected appendicitis. Whether other imaging techniques, such as CT or antibody-assisted scintigraphy [21], can contribute to an improvement in the diagnosis of acute appendicitis at reasonable costs is doubtful [8]. The role of CT in this connection is assessed controversially.…”

Poor sensitivity of 99mTc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis

“…On the other side, a normal appendix is reported in 15-40 % of patients who undergo appendectomy [17]. Different imaging modalities have been used with varying accuracy to address this dilemma, and different scintigraphic techniques have been reported to contribute to the diagnosis of suspicious appendicitis [5,[21][22][23]. 99m Tc-labeled UBI is a synthetic antimicrobial peptide, which is used recently for detection of fungal and bacterial infections with high sensitivity and specificity [10,24,25].…”