96. ACPA-Positive and ACPA-Negative Rheumatoid Arthritis Differ in their Requirements for Combination Dmards and Corticosteroids

Seegobin, Seth; Margaret, H.; Dahanayake, Chanaka; Cope, Andrew; Scott, David; Lewis, Cathryn M.; Scott, Ian C.

doi:10.1093/rheumatology/keu101.017

Cited by 3 publications

(2 citation statements)

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“…RA is distinguished by the presence of autoantibodies such as rheumatoid factor (RF) and antibodies directed against citrullinated peptides (ACPAs) (2,3). ACPAs are considered the autoantibodies specific for RA and they have been related to specific genetic association patterns (4), more aggressive phenotypes, and different responses to treatment (5).…”

Section: Introduction To Inflammatory Arthritismentioning

confidence: 99%

Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk

et al. 2022

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Liver disease is one of the most important causes of morbidity and mortality worldwide whose prevalence is dramatically increasing. The first sign of hepatic damage is inflammation which could be accompanied by the accumulation of fat called non-alcoholic fatty liver disease (NAFLD), causing damage in the hepatocytes. This stage can progress to fibrosis where the accumulation of fibrotic tissue replaces healthy tissue reducing liver function. The next stage is cirrhosis, a late phase of fibrosis where a high percentage of liver tissue has been replaced by fibrotic tissue and liver functionality is substantially impaired. There is a close interplay of cardiovascular disease (CVD) and hepatic alterations, where different mechanisms mediating this relation between the liver and systemic vasculature have been described. In chronic inflammatory diseases such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), in which the CVD risk is high, hepatic alterations seem to be more prevalent compared to the general population and other rheumatic disorders. The pathogenic mechanisms involved in the development of this comorbidity are still unraveled, although chronic inflammation, autoimmunity, treatments, and metabolic deregulation seem to have an important role. In this review, we will discuss the involvement of liver disease in the cardiovascular risk associated with inflammatory arthritis, the pathogenic mechanisms, and the recognized factors involved. Likewise, monitoring of the liver disease risk in routine clinical practice through both, classical and novel techniques and indexes will be exposed. Finally, we will examine the latest controversies that have been raised about the effects of the current therapies used to control the inflammation in RA and PsA, in the liver damage of those patients, such as methotrexate, leflunomide or biologics.

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Section: Introduction To Inflammatory Arthritismentioning

confidence: 99%

Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk

et al. 2022

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“…The anti-cyclic citrullinated peptides (anti-CCP) test is used to identify autoantibodies against citrullinated peptides and classify patients as having anti-CCP positive RA or anti-CCP negative RA. These two patient groups can be considered as two different disease entities with differences in, among other things, risk factors, disease severity, and prognosis (62,63). Testing positive for anti-CCP usually indicates a more severe form of RA disease and it is suggested to treat it more aggressively compared to anti-CCP negative diagnosed RA (64)(65)(66).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Insight into the Autoantibody Landscape in Rheumatoid Arthritis for Companion Diagnostics

Poulsen¹

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Phytochemicals from medicinal plants from African forests with potentials in rheumatoid arthritis management

Aloke

Ohanenye

Aja

et al. 2022

Journal of Pharmacy and Pharmacology

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Objectives Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation, pain, and cartilage and bone damage. There is currently no cure for RA. It is however managed using nonsteroidal anti-inflammatory drugs, corticosteroids and disease-modifying anti-rheumatic drugs, often with severe side effects. Hidden within Africa’s lush vegetation are plants with diverse medicinal properties including anti-RA potentials. This paper reviews the scientific literature for medicinal plants, growing in Africa, with reported anti-RA activities and identifies the most abundant phytochemicals deserving research attention. A search of relevant published scientific literature, using the major search engines, such as Pubmed/Medline, Scopus, Google Scholar, etc. was conducted to identify medicinal plants, growing in Africa, with anti-RA potentials. Key findings Twenty plants belonging to 17 families were identified. The plants are rich in phytochemicals, predominantly quercetin, rutin, catechin, kaempferol, etc., known to affect some pathways relevant in RA initiation and progression, and therefore useful in its management. Summary Targeted research is needed to unlock the potentials of medicinal plants by developing easy-to-use technologies for preparing medicines from them. Research attention should focus on how best to exploit the major phytochemicals identified in this review for the development of anti-RA ‘green pharmaceuticals’.

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96. ACPA-Positive and ACPA-Negative Rheumatoid Arthritis Differ in their Requirements for Combination Dmards and Corticosteroids

Cited by 3 publications

References 0 publications

Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk

Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk

Insight into the Autoantibody Landscape in Rheumatoid Arthritis for Companion Diagnostics

Phytochemicals from medicinal plants from African forests with potentials in rheumatoid arthritis management

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