91318769 Prevention of postmenopausal osteoporosis - a comparative study of exercise, calcium supplementation, and hormone-replacement therapy

Prince, Richard; Smith, Mitchell T.; Dick, Ian M.; Price, Ron; Webb, P. Garcia; Henderson, Nora; Harris, Margaret

doi:10.1016/0378-5122(92)90078-i

Cited by 110 publications

(156 citation statements)

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“…In addition, it has been demonstrated that estrogen deficiency after menopause is associated with increased renal Ca 2+ loss and intestinal Ca 2+ malabsorption, which can be corrected by estrogen replacement therapy (Colin et al 1999;Gennari et al 1990;Nordin et al 1991;Prince et al 1991). Therefore, the effect of estrogen on the proteins involved in active Ca 2+ (re)absorption was investigated.…”

Section: Estrogenmentioning

confidence: 99%

“…As previously mentioned, the deleterious effects of estrogen deficiency after menopause, leads to a negative Ca 2+ balance associated with renal Ca 2+ loss, intestinal Ca 2+ malabsorption and postmenopausal osteoporosis, which can be corrected with estrogen replacement therapy (Colin et al 1999;Nordin et al 1991;Prince et al 1991;Young and Nordin 1969). In addition, estrogen has been implicated in the protection against Ca 2+ nephrolithiasis via an increased reabsorption of Ca 2+ .…”

Section: Estrogens and Postmenopausal Osteoporosismentioning

confidence: 99%

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The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

Abel

Hoenderop

Bindels

2005

Naunyn-Schmiedeberg's Arch Pharmacol

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The epithelial Ca 2+ channels TRPV5 and TRPV6 represent a new family of Ca 2+ channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca 2+ entry mechanism in active Ca 2+ transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca 2+ (re)absorption makes it a prime target for regulation to maintain Ca 2+ balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca 2+ channels.

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Section: Estrogenmentioning

confidence: 99%

Section: Estrogens and Postmenopausal Osteoporosismentioning

confidence: 99%

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

Abel

Hoenderop

Bindels

2005

Naunyn-Schmiedeberg's Arch Pharmacol

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“…This is associated with osteoporosis and an increased fracture risk. Ca alone without oestrogens cannot fully ameliorate post-menopausal bone loss, but Ca supplementation of 1000 mg daily with exercise does slow bone loss (Prince et al 1991). Although Ca supplementation may be necessary for certain groups of elderly people, it may be harmful in patients with a history of Ca stones, primary hyperparathyroidism, sarcoidosis or renal hypercalcuria (Heaney et al 1982).…”

Section: Calcium and Vitamin Dmentioning

confidence: 99%

Nutrition, ageing and ill health

1998

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There are physical, mental, social and environmental changes which take place with ageing; for example, decreased physical activity, increase in body fat, decrease in lean body mass and consequently decreased energy intake may be associated with physiological functions that affect metabolism, nutrient intake, physical activity and risk of disease. There are now many studies which have found that undernutrition is prevalent and often unrecognized in patients admitted to hospitals and institutions. There is also evidence which links protein-energy undernutrition or its markers with clinical outcomes in acute and non-acute hospital settings and that nutritional supplements can improve outcomes in some of these settings. However, most clinically-available nutrition screening instruments lack sensitivity and specificity, and abnormal nutritional indicators may simply reflect effects of age, functional disability, or severe underlying disease. Thus, causal relationship cannot be assumed without a sufficiently powerful intervention study which adequately adjusts for the effects of non-nutritional factors, such as the number and severity of co-morbid conditions on clinical outcome.

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“…Inadequate calcium ingestion has been documented in many populations of older persons around the world. Several large-scale intervention studies have been completed in an attempt to arrive at a calcium requirement for older persons based on the effect of calcium intakes on bone mineral loss (225)(226)(227). These studies were conducted using calcium supplements with a diverse range of dietary calcium intakes.…”

Section: Calciummentioning

confidence: 99%

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

Raman

Pal

Ganesan

et al. 2016

Eye

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91318769 Prevention of postmenopausal osteoporosis - a comparative study of exercise, calcium supplementation, and hormone-replacement therapy

Cited by 110 publications

References 0 publications

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

Nutrition, ageing and ill health

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

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