9-α-hydroxyparthenolide, a novel antitumor sesquiterpene lactone fromAnvillea garcini (Burm.) DC1

Abstract

SPECIALIAThe editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. -Les auteurs sont seuls responsables des opinions exprim6es dans ces br6ves communications. -Ftir die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. -Per le brevi comunicazioni 6 responsabile solo l'autore. -OTBeTCTBermocw, aa r~opoTKne coo6~ueHn~ HeceT HcKJnOqHTeJIbHO aBYOp. --Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves. 9-a- Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, W. Lafayette (Indiana 47907, USA), 5August 1980Summary. A novel sesquiterpene lactone, 9-a-hydroxyparthenolide (1) was isolated from a chloroform extract of Anvillea garcini that was collected in Iran. The structure of 1 was assigned on the basis of high field NMR decoupling experiments

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

“…9-a-Hydroxyparthenolide (28), isolated from Anvillea garcini, has shown activity in both the 9 KB cell culture and P388 mouse leukemia test systems (Tyson et al, 1981). Compound 28 was evaluated by an in vitro disease-oriented antitumor screen, which determinates cytotoxic effects against a panel of approximately 60 human tumor cell lines.…”

Centrifugal partition chromatography elution gradient for isolation of sesquiterpene lactones and flavonoids from Anvillea radiata

“…The chemical shifts are reported in ppm (ı scale) and all coupling constants (J) values are in hertz (Hz). Assignments were based on 1 H NMR and 13 C NMR and two-dimensional NMR spectra as homonuclear and hetero-nuclear correlations, as well as comparison with the data in the literature [11,13,28].…”

“…Conventional procedures (maceration, liquid-liquid extraction, silica gel column chromatography) have been previously used to isolate small amounts of germacranolides from different CHCl 3 extracts of the aerial parts of A. garcinii or A. radiata. The Germacranolides extracted from A. radiata have been identified as 9␣-hydroxyparthenolide [11] 9␤-hydroxyparthenolide [12], 9␤-hydroxy-1␤,10␣-epoxyparthenolide [12], 9␣-hydroxy-1␤,10␣-epoxyparthenolide [13], 8␣,9␣-epoxyparthenolide [14], parthenolid-9-one [13] and cis-parthenolid-9-one [15]. In addition, thirteen minor flavonoids (four aglycones and nine flavonol glycosides), have been reported [16].…”

Sesquiterpene Lactones of Iranian Compositae Family (Astraceae); Their Chemical Constituents and Anti-plasmodial Properties of Tehranolide (A.Review)

“…From A. garcini (Burn.) DC flavones 41 and 9α-hydroxyparthenolide (48) 42 were reported. An investigation of a sample collected in the South of Iran gave in addition to 9α-hydroxyparthenolide (48), two further lactones, 49 (the epimer of 48) and 50 (the epoxide of 49).…”