9.1 A Current-Sensing Front-End Realized by A Continuous-Time Incremental ADC with 12b SAR Quantizer and Reset-Then-Open Resistive DAC Achieving 140dB DR and 8ppm INL at 4kS/s

Wu, Su-Hao; Shu, Yun-Shiang; Chiou, Albert Yen-Chih; Huang, Wei-Hsiang; Chen, Zhuo; Hsieh, Hung-Yi

doi:10.1109/isscc19947.2020.9062990

Cited by 29 publications

(7 citation statements)

References 4 publications

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“…This calibration also compensates the AAF and ADC gain variability. In line with the measurement required for the EGOFET transfer curve acquisition, and matching most biosensor application requirements, the SNR has been measured using DC input currents [28]. The same approach has also been adopted in [29] where the DR is calculated with DC signals.…”

Section: B Cmos Si-ic Measurementsmentioning

confidence: 99%

“…From Fig. 12(b) a DC dynamic range of 137 dB, defined as ratio between the largest input signal and the smallest that ensures an SNR>0 dB ( [28], [30]), can be extracted. It should be noted that this level of performance is not strictly needed for the single molecule detection procedure, for which an accurate estimation of the threshold is sufficient, but is useful for a research system as the one built in this work.…”

Section: B Cmos Si-ic Measurementsmentioning

confidence: 99%

“…The proposed acquisition system has been compared to the state of the art of both analogue and mixed-signal current sensitive front-ends. Mixed-signal solutions achieve on average higher FoM [28] thanks to the direct interface of the sensor with the current-based ADC. This kind of topologies have been added to the benchmarking for a complete stateof-the-art evaluation, but they cannot be used without additional circuitry in multiplexed systems as the one proposed, where each sensor in a column must be kept constantly biased during a measurement procedure.…”

Section: B Cmos Si-ic Measurementsmentioning

confidence: 99%

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A 4 × 4 Biosensor Array With a 42-μW/Channel Multiplexed Current Sensitive Front-End Featuring 137-dB DR and Zeptomolar Sensitivity

Genco

Fattori

Harpe

et al. 2022

IEEE Open J. Solid-State Circuits Soc.

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This paper presents a multiplexed current sensitive readout for la bel-free zeptomolar-sensitive detectors realized with large area Electrolyte Gated Organic Thin Film Transistors (EGOFETs). These highly capacitive biosensors are multiplexed using an OTFT line driver and OTFT switches, and interfaced to a 65-nm Si CMOS, low power, pA-sensitive front-end. The Si chip performs analogue-to-digital conversion and data transmission to a microcontroller too. A current domain interface is used to transmit the signals coming from multiple biosensors to the 1.2 V-supply CMOS Si-IC via the 30V-supply OTFT electronics. Exploiting an analogue module implemented in the Si-IC, the EGOFETs are precisely biased, even in presence of a large OTFT multiplexer resistance. The CMOS current sensitive front-end achieves a dynamic range (DR) of 137 dB and a power consumption of 42 µW per channel reaching a state-of-the-art DR-power-bandwidth FOM of 208 dB. The front-end has been designed with a first stage programmable-gain, active-feedback transimpedance amplifier topology that, contrary to common current-sensitive front-end solutions, is not affected by the sensor capacitance. The system has been validated with different concentrations of human IgG and IgM proteins using both a single sensor and a 4x4 array of EGOFETs. Thanks to the multiplexing strategy and the lowcosts of its modules, the system here presented has the potential to enable widespread use of precision diagnostic with extreme sensitivity even in point-of-care and low-resource settings.

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Section: B Cmos Si-ic Measurementsmentioning

confidence: 99%

Section: B Cmos Si-ic Measurementsmentioning

confidence: 99%

Section: B Cmos Si-ic Measurementsmentioning

confidence: 99%

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A 4 × 4 Biosensor Array With a 42-μW/Channel Multiplexed Current Sensitive Front-End Featuring 137-dB DR and Zeptomolar Sensitivity

Genco

Fattori

Harpe

et al. 2022

IEEE Open J. Solid-State Circuits Soc.

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“…Till now, CMOS current readout is the most creditable technique used in bio-sensing systems, such as photoplethysmography monitoring, molecular-concentration detection, and bioluminescent protein sensing, etc. [1]. As an example, some of the most used biosensors are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Review and Analysis of CMOS Current Readout Circuits for Biosensing Applications

Awan

Wang

Quadir

et al. 2021

2021 IEEE International Symposium on Circuits and Systems (ISCAS)

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CMOS current readout is a critical circuit block for various applications like bio-sensing. This paper presents an overview of CMOS current readout techniques and analyze their merits and demerits, including noise floor, sensitivity, and achievable system bandwidth. Mainly, the practical applicability of individual technique/design for integrated low-noise bio-sensing applications is discussed. To present a thorough insight of the state-of-the-art, most recent and relevant articles published in the literature related to the current sensing interface are summarized and compared. The paper identified the primary DC current rejection schemes, where each approach and its limitations are discussed and shown that each system comes with its limits.

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“…Similarly, with high temperature the AC/DC ratio is increases significantly. Considering all the above mention challenges associated with the PPG sensors, in the recent past, many researchers have dedicated their effoert to developed a long time continuous and accurate measurement of the bio sign using the PPG devices (Wu et al 2020;Marefat et al 2020;Lin et al 2019). Khan et al (2019) proposed a flexible organic sensor for the health monitoring.…”

Section: Introductionmentioning

confidence: 99%

External temperature sensor assisted a new low power photoplethysmography readout system for accurate measurement of the bio-signs

Pandey

Chao

2020

Microsyst Technol

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This study presents an external temperature sensor assisted a new low power, time-interleave, wide dynamic range, and low DC drift photoplethysmography (PPG) signal acquisition system to obtain the accurate measurement of various bio signs in real-time. The designed chip incorporates a 2-bit control programmable transimpedance amplifier (TIA), a high order filter, a 3:8 programmable gain amplifier (PGA) and 2 9 2 organic light-emitting diode (OLED) driver. Temperature sensor is used herein to compensate the adverse effect of low-skin-temperature on the PPG signal quality. The analog front-end circuit is implemented in the integrated chip with chip area of 2008 lm 9 1377 lm and fabricated via TSMC T18 process. With the standard 1.8 V, the experimental result shows that the measured current sensing range is 20 nA-100 uA. The measured dynamic range of the designed readout circuit is 80 dB. The estimated signal to noise ratio is 60 dB@1 uA, and the measured input referred noise is 60.2 pA/Hz. The total power consumption of the designed chip is 31.32 lW (readout) ? 1.62 mW (OLED driver@100% duty cycle). The non-invasive PPG sensor is applied to the wrist artery of the 40 healthy subjects for sensing the pulsation of the blood vessel. The experimental results show that for every 1°C decrease in mean ambient temperature tends to 0.06 beats/min, 0.125 mmHg and 0.063 mmHg increase in hear rate (HR), systolic (SBP) and diastolic (DBP), respectively. Similarly, for every 1°C increase in mean ambient temperature tends to 0.13 beats/min, 0.601 mmHg and 0.121 mmHg increase in HR, SBP and DBP, respectively. The measured accuracy and standard error for the HR estimation are 96%, and-0.022 ± 2.589 beats/minute, respectively. The oxygen stauration (S p O 2) measurement results shows that the mean absolute percentage error is less than 5%. The resultant errors for the SBP and DBP measurement are-0.318 ± 5.19 mmHg and-0.5 ± 1.91 mmHg, respectively.

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9.1 A Current-Sensing Front-End Realized by A Continuous-Time Incremental ADC with 12b SAR Quantizer and Reset-Then-Open Resistive DAC Achieving 140dB DR and 8ppm INL at 4kS/s

Cited by 29 publications

References 4 publications

A 4 × 4 Biosensor Array With a 42-μW/Channel Multiplexed Current Sensitive Front-End Featuring 137-dB DR and Zeptomolar Sensitivity

A 4 × 4 Biosensor Array With a 42-μW/Channel Multiplexed Current Sensitive Front-End Featuring 137-dB DR and Zeptomolar Sensitivity

Review and Analysis of CMOS Current Readout Circuits for Biosensing Applications

External temperature sensor assisted a new low power photoplethysmography readout system for accurate measurement of the bio-signs

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