8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice

Rice, Thomas W.; Patil, Deepa T.; Blackstone, Eugene H.

doi:10.21037/acs.2017.03.14

Cited by 559 publications

(413 citation statements)

References 49 publications

(62 reference statements)

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“…25 In addition to dynamic changes in risk factors in both elevating the risk (GERDs, high-risk alcohol consumption, and obesity in men) and lowering the risk (decrease in smoking prevalence), it is possible that gastric cancer occurred in cardia was diagnosed as adenocarcinoma occurred in the lower esophagus until AJCC 8 edition clearly defined esophago-gastric junction cancer. 26 Stomach cancer in Korea including cardia, body, and antrum is decreasing 10 , therefore, we cannot completely rule out the possibility of potential misclassification of the cancer site.…”

Section: Esophageal Cancer Epidemiology In Koreamentioning

confidence: 98%

Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database

Shin

Won

Jung

et al. 2018

J of Gastro and Hepatol

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Background and Aim: The diagnostic and therapeutic modalities of esophageal cancer have recently improved in Asia, and its prognosis is expected to change. This study provides a population-based report on the epidemiology of esophageal cancer in Korea. Methods: Cancer incidence data from 1999 to 2013 were obtained from the Korea Central Cancer Registry, covering the entire population. Age-standardized incidence rates and annual percent changes were calculated according to subsites and histological types. Fiveyear relative survival rates were estimated for cases diagnosed between 1993 and 2013. Relative excess rates were compared between patients diagnosed from 2009 to 2013 and 2006 to 2008. Results: The age-standardized incidence rates decreased from 8.8 per 100 000 populations in 1999 to 5.9 in 2013 with an annual percent change of À2.6% in men and À2.2% in women. The most common histological type was squamous cell carcinoma, accounting for 90.2% of all esophageal cancers in 2013, followed by adenocarcinomas (3.1%), and their incidences decreased. The proportion of localized and regional cancer tended to increase compared with that of distant cancer. Five-year relative survival of squamous cell carcinoma improved from 12.1% (1993)(1994)(1995) Conclusions:The incidence of esophageal cancer has decreased in Korea for the past 15 years, and 5-year survival rates have improved significantly. These increases may be attributable to more effective detection of early-stage disease.

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Section: Esophageal Cancer Epidemiology In Koreamentioning

confidence: 98%

Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database

Shin

Won

Jung

et al. 2018

J of Gastro and Hepatol

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“…Patients were staged with endoscopy, CT-scan, and PET-Scan before neoadjuvant therapy and classified as per the 8th edition of UICC staging system. 16 Pathological response to neoadjuvant therapy was graded accordingly to Ryan score. 17 Patients were followed with clinical evaluation, peripheral blood analysis, CT-scan, and endoscopy.…”

Section: Methodsmentioning

confidence: 99%

The value of cellular components of blood in the setting of trimodal therapy for esophageal cancer

Tustumi

Takeda

Viyuela

et al. 2019

Journal of Surgical Oncology

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Background Inflammation status plays an important role in the natural history of malignancy. Consequently, hematological markers of systemic inflammation may predict prognosis in neoplasms. This study evaluated the value of cellular blood components changes during neoadjuvant chemoradiotherapy followed by esophagectomy for cancer in predicting prognosis. Methods A cohort of 149 patients was analyzed. Cellular components of blood were assessed before neoadjuvant therapy (A); before surgery (B); and 3 to 5 months after surgery (C); for the following outcomes: pathological response, overall survival (OS), and disease‐free survival (DFS). Univariate and multivariate Cox regression models were applied to evaluate the independent prognostic significance of blood count variables. Results Low hematocrit (Ht) (C) (HR, 0.85; 95% CI, 0.79‐0.92) and high neutrophil‐to‐lymphocyte ratio (NLR) (C) (HR, 1.07; 95% CI, 1.07‐1.10) were related to poor OS. Low Hb (C) (HR, 0.72; 95% CI, 0.58‐0.88), red cell distribution width (RDW) (C‐A) (HR, 1.16; 95% CI, 1.02‐1.31), and NLR (C‐A) (1.06; 95% CI, 1.03‐1.09) were related to poor DFS. RDW (B‐A) (HR, 1.15; 95% CI, 1.08‐1.22), RDW (C) (HR, 1.12; 95% CI, 1.04‐1.2), NLR (C) (HR, 1.12; 95% CI, 1.08‐1.17) were related to systemic recurrence. Conclusion Variables of routine blood count are easily assessable and their changes throughout trimodal therapy for esophageal carcinoma provide important information for cancer patient's prognosis.

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“…The longitudinal location within the esophagus was divided into three divisions of upper, middle and lower according to Union for International Cancer Control. 10 The circumferential location within the esophagus was divided into four divisions. As for the endoscopic radial orientation, the extrinsic esophageal compression of the left main bronchus was a landmark.…”

Section: Longitudinal and Cross-sectional Location Of The Lesionmentioning

confidence: 99%

Clinical characteristic of esophageal cancer without lugol‐voiding lesions in the background esophagus

Kuwabara¹,

Chiba²,

Tachikawa³

et al. 2020

Digestive Endoscopy

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Lugol chromoendoscopy is useful for the detection of early esophageal squamous cell cancer (ESCC). Multiple lugol-voiding lesions (LVLs) on lugol chromoendoscopy are associated with a very high risk of multiple cancers arising in the esophagus. Due to the widespread use of narrow band image technology in many institutions, esophageal cancer without LVLs in the background esophagus is sometimes detected. This retrospective study aims to clarify the clinical characteristic of esophageal cancer without LVLs in the background esophagus. A total of 191 consecutive patients with 204 ESCCs had undergone endoscopic submucosal dissection (ESD) from 2011 and 2014. Amongst these lesions, the number of LVLs in the background esophagus per endoscopic view was counted excluding main lesion, and the grading was divided into no LVLs ESCC (nL-ESCC) group and LVLs ESCC (L-ESCC) group. This study evaluated the clinical characteristics and the cumulative incidence of metachronous ESCC after ESD in both groups. Thirty-six patients with 36 lesions and 155 patients with 168 lesions were separated into the nL-ESCC group and L-ESCC group, respectively. On multivariate analysis, the nL-ESCC group was found to be more common in females, who were nondrinkers, or with erosive esophagitis. During follow-up periods, the cumulative incidence of metachronous ESCC at 3-years was 14.4% and 0.00% in the L-ESCC and nL-ESCC groups, respectively (P < 0.01). Our study showed that esophageal cancer without LVLs in the background esophagus was mostly occurred in females, who were non-drinkers, or with erosive esophagitis, which are uncommon features of ESCC.

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8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice

Cited by 559 publications

References 49 publications

Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database

Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database

The value of cellular components of blood in the setting of trimodal therapy for esophageal cancer

Clinical characteristic of esophageal cancer without lugol‐voiding lesions in the background esophagus

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