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doi:10.18632/oncotarget.v10i34

Cited by 1 publication

(2 citation statements)

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“…The leukocytes are then treated with a photosensitizing agent (8-methoxypsoralen) and exposed to ultraviolet-A (UVA) irradiation, before reinfusion (24,25). After treatment, a large proportion of leukocytes undergo apoptosis, and subsequently phagocytosis by immature dendritic cells, promoting immunomodulatory effects (25,28). The exact mechanisms of action by which ECP mediates its effects have not been fully characterized; however it is hypothesized that ECP works through a combination of dendritic cell initiation, modification of cytokine profiles and stimulation of T-cells (25).…”

Section: Extracorporeal Photopheresismentioning

confidence: 99%

“…IL-10 and TGF-b) (25,29,34). These multiple effects of ECP, including anti-tumor immunity, inhibition of inflammation vis immune tolerance and modulation of genes involved in cell adhesion and diapedesis, work to restore healthy immune function by immune modulation (29-33); as such, it is important to note that, unlike conventional immunosuppressive therapies, ECP promotes regulatory T-cell production without inducing global IS (24,26,28).…”

Section: Extracorporeal Photopheresismentioning

confidence: 99%

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The value of extracorporeal photopheresis as an immunosuppression-modifying approach in solid organ transplantation: a potential solution to an unmet medical need

Augusto,

Benden,

Diekmann

et al. 2024

Front. Immunol.

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Allograft rejection is a critical issue following solid organ transplantation (SOT). Immunosuppressive therapies are crucial in reducing risk of rejection yet are accompanied by several significant side effects, including infection, malignancy, cardiovascular diseases, and nephrotoxicity. There is a current unmet medical need with a lack of effective minimization strategies for these side effects. Extracorporeal photopheresis (ECP) has shown potential as an immunosuppression (IS)-modifying technique in several SOT types, with improvements seen in acute and recurrent rejection, allograft survival, and associated side effects, and could fulfil this unmet need. Through a review of the available literature detailing key areas in which ECP may benefit patients, this review highlights the IS-modifying potential of ECP in the four most common SOT procedures (heart, lung, kidney, and liver transplantation) and highlights existing gaps in data. Current evidence supports the use of ECP for IS modification following SOT, however there is a need for further high-quality research, in particular randomized control trials, in this area.

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Section: Extracorporeal Photopheresismentioning

confidence: 99%