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Bouyou-Akotet, Marielle Karine; Ionete-Collard, Denisa E; Mabika-Manfoumbi, Modeste; Kendjo, Éric; Matsiégui, Pierre-Blaise; Mavoungou, Elie; Kombila, Maryvonne

doi:10.1186/1475-2875-2-18

Cited by 102 publications

(48 citation statements)

References 29 publications

(31 reference statements)

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“…The rates confirm recent reports in pregnant Nigerian women [5], [21] and are also in agreement with findings from Malawi, Gabon and Ghana, but lower than in Western Kenya [22]–[25]. The latter areas have similar endemic rates to that in Nigeria.…”

Section: Discussionsupporting

confidence: 91%

Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

et al. 2011

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BackgroundHypertension is an increasing health issue in sub-Saharan Africa where malaria remains common in pregnancy. We established a birth cohort in Nigeria to evaluate the early impact of maternal malaria on newborn blood pressure (BP).MethodsAnthropometric measurements, BP, blood films for malaria parasites and haematocrit were obtained in 436 mother-baby pairs. Women were grouped to distinguish between the timing of malaria parasitaemia as ‘No Malaria’, ‘Malaria during pregnancy only’ or ‘Malaria at delivery’, and parasite density as low (<1000 parasites/µl of blood) and high (≥1000/µl).ResultsPrevalence of maternal malaria parasitaemia was 48%, associated with younger maternal age (p<0.001), being primigravid (p = 0.022), lower haematocrit (p = 0.028). High parasite density through pregnancy had the largest effect on mean birth indices so that weight, length, head and mid-upper arm circumferences were smaller by 300 g, 1.1 cm, 0.7 cm and 0.4 cm respectively compared with ‘No malaria’ (all p≤0.005). In babies of mothers who had ‘malaria at delivery’, their SBPs adjusted for other confounders were lower respectively by 4.3 and 5.7 mmHg/kg compared with ‘malaria during pregnancy only’ or ‘none’. In contrast the mean newborn systolic (SBP) and diastolic BPs (DBP) adjusted for birth weight were higher by 1.7 and 1.4 mmHg/kg respectively in babies whose mothers had high compared with low parasitaemia.ConclusionsAs expected, prenatal malarial exposure had a significant impact on fetal growth rates. Malaria at delivery was associated with the lowest newborn BPs while malaria through pregnancy, which may attenuate growth of the vascular network, generated higher newborn BPs adjusted for size. These neonatal findings have potential implications for cardiovascular health in sub-Saharan Africa.

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Section: Discussionsupporting

confidence: 91%

Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

et al. 2011

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“…In contrast, a study from Gabon revealed that primigravida and young pregnant women were associated with increased malaria susceptibility. Although not statistically significant, based on microscopy results, primigravida women demonstrated a higher median parasite density (5200 parasites/μl) than multigravida (1560 parasites/μl) [34]. This is similar to a report from Nigeria, where primigravida women demonstrated higher parasitaemia than multigravida women [35].…”

Section: Discussionsupporting

confidence: 71%

Performance of loop-mediated isothermal amplification (LAMP) for the diagnosis of malaria among malaria suspected pregnant women in Northwest Ethiopia

Tegegne

Getie

Lemma

et al. 2017

Malar J

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Background: Malaria is a major public health problem and an important cause of maternal and infant morbidity in sub-Saharan Africa, including Ethiopia. Early and accurate diagnosis of malaria with effective treatment is the best strategy for prevention and control of complications during pregnancy and infant morbidity and mortality. However, laboratory diagnosis has relied on the identification of malaria parasites and parasite antigens in peripheral blood using Giemsa-stained microscopy or rapid diagnostic tests (RDTs) which lack analytical and clinical sensitivity. The aim of this study was to evaluate the performance of loop-mediated isothermal amplification (LAMP) for the diagnosis of malaria among malaria suspected pregnant women in Northwest Ethiopia. Methods:A cross sectional study was conducted from January to April 2016. Pregnant women (n = 87) suspected of having malaria at six health centres were enrolled. A venous blood sample was collected from each study subject, and analysed for Plasmodium parasites by microscopy, RDT, and LAMP. Diagnostic accuracy outcome measures (sensitivity, specificity, predictive values, and Kappa scores) of microscopy, RDT and LAMP were compared to nested polymerase chain reaction (nPCR) as the gold standard. Specimen processing and reporting times were documented.Results: Using nPCR as the gold standard technique, the sensitivity of microscopy and RDT was 90 and 70%, and the specificity was 98.7 and 97.4%, respectively. LAMP assay was 100% sensitive and 93.5% specific compared to nPCR. Conclusions:This study showed higher sensitivity of LAMP compared to microscopy and RDT for the detection of malaria in pregnancy. Increased sensitivity and ease of use with LAMP in point-of-care testing for malaria in pregnancy was noted. LAMP warrants further evaluation in intermittent screening and treatment programmes in pregnancy.

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“…Their finding revealed that susceptibility is more marked in second trimester and early third trimester than first trimester. Other studies by Ohalete et al [23], Brabin [28], Nwagha et al [31] and Bouvon-Akotet et al [32]; also recorded high prevalence rate in second trimester.…”

Section: Discussionmentioning

confidence: 82%

Rapid Diagnostic Test Kits Detection of Malaria Parasites among Pregnant Women Attending Antenatal in Selected Hospitals in Anyigba, Kogi State, Nigeria

Yaro¹,

Iyaji²,

Tope³

2017

ABB

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A study was carried out to determine the status of malaria in four (4) selected hospitals in Anyigba, Dekina Local Government Area, Kogi State. A total of 300 pregnant women attending antenatal were tested for malaria parasite using rapid diagnostic test kits. Blood samples were obtained from finger by pricking and tested for malaria parasites. Structured questionnaires were administered to the pregnant women to obtain relevant information on the clinical and social aspects of malaria. A prevalence of 13.0% (39 women) was observed among pregnant women in Anyigba. Grimard Hospital and Egume General Hospital had the highest prevalence of 14.7% each; Maria Goretti Hospital had a prevalence of 13.3%, while KSUTH had the least prevalence of 9.3%. Age prevalence revealed that women with age < 20 years had the highest prevalence of 29.4% which was significant (p > 0.05) from the other age categories. Unemployed and women in their second trimester had the highest prevalence of 17.1% and 16.0% respectively. On the gravidity of the pregnant women, primigravidae (21.9%) was higher than multigravidae (10.6%) significantly (p < 0.05). Women from a polygamous family had a prevalence of 15.2% higher than those from monogamous family with a prevalence of 12.4%. The findings of this study revealed that malaria continues to exert significant public health and economic burden among pregnant women in parts of Dekina Local Government Area of Kogi State. Continuous efforts at providing necessary information by relevant health organizations are needed to control and reduce incidence of malaria in this area.

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Cited by 102 publications

References 29 publications

Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

Performance of loop-mediated isothermal amplification (LAMP) for the diagnosis of malaria among malaria suspected pregnant women in Northwest Ethiopia

Rapid Diagnostic Test Kits Detection of Malaria Parasites among Pregnant Women Attending Antenatal in Selected Hospitals in Anyigba, Kogi State, Nigeria

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