Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

Ayoola, Oluwagbemiga Oluwole; Gemmell, Isla; Omotade, Olayemi O.; Adeyanju, Olusoji; Cruickshank, J.; Clayton, Peter E.

doi:10.1371/journal.pone.0024548

Cited by 15 publications

(20 citation statements)

References 41 publications

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“…Even with recruitment at the immunisation clinic, we were able to recruit only a small proportion of this category of mothers. Despite the baseline underrepresentation of mothers giving birth at home, the distribution of newborn anthropometric measurements was consistent with other Nigerian studies and INTERGROWTH-21 [40][41][42][43]. In the sub-study, we observed that the women giving birth at home were less educated and displayed lower utilisation of maternal health services including antenatal care, attendance by health professional during delivery and postnatal family planning.…”

supporting

confidence: 87%

“…We assessed the external validity of the anthropometric measurements for the pilot KID Birth Cohort Study by comparing with standards of other Nigerian studies and INTERGROWTH-21 (Table S2). [40][41][42][43] The sub-study participants included individuals listed in CEGROMS at 22 months of the pilot study (October 2018) and have a phone number. Risk difference (RD) was used to assess the association of baseline maternal characteristics and participation in the sub-study.…”

Section: Discussionmentioning

confidence: 99%

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Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Kana

Ahmed

Ashiru

et al. 2020

Paediatric Perinatal Epid

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Background Developing countries bear the burden of childhood stunting but lack resources for cohort studies to develop preventive strategies. To enable future prospective studies, we designed and tested the Child Electronic Growth Monitoring System (CEGROMS) using a readily available electronic data capture platform, the Research Electronic Data Capture (REDCap). Objectives To demonstrate the feasibility of using CEGROMS for data collection for a pilot study for the Kaduna Infant Development (KID) Birth Cohort Study in Nigeria. Methods CEGROMS consists of the data capture form for growth monitoring, a central cloud server, electronic tablets, and desktop computer. We implemented the pilot study in 2017‐2019 at the Barau Dikko Teaching Hospital, Kaduna, Nigeria. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for completeness of baseline data (relative to individuals with incomplete data) and completion of follow‐up at different time points (relative to individuals with no follow‐up visit) by the participant characteristics. Complete data were defined as date of birth, sex, and birthweight recorded at recruitment. Results Among 3152 infant records in CEGROMS, 2789 (88.5%) had complete data. Of these, 1905 (68.3%) had at least one follow‐up visit. The main determinants of data completeness were health facility delivery (OR 19.17, 95% CI 13.65, 26.92) and tertiary education (OR 3.54, 95% CI 2.69, 4.67). Follow‐up was greater for women with tertiary education (OR 1.33, 95% CI 1.06, 1.51 for at least one visit). Maternal education is associated with completeness and follow‐up (following adjustments for parity and employment). Conclusions The CEGROMS electronic data collection system enables complete and consistent data collection. The data will enable design of strategies to improve follow‐up in the future implementation of the birth cohort study.

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confidence: 87%

Section: Discussionmentioning

confidence: 99%

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Kana

Ahmed

Ashiru

et al. 2020

Paediatric Perinatal Epid

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“…Weight SDS <−1 occurred in 42% and 53%, and length SDS <−1 in 36% and 37% at birth and 12 months, respectively. Mean birth anthropometry and SDSs of all malaria-exposed infants, sexes combined, were globally and significantly smaller than those not exposed (as detailed previously) 14 but differed (Table 1). At 12 months, these effects persisted in boys.…”

Section: Anthropometry Growth and Bp By Sex And Effect Of Maternal supporting

confidence: 54%

The Impact of Malaria in Pregnancy on Changes in Blood Pressure in Children During Their First Year of Life

et al. 2014

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Abstract-We established a maternal birth cohort in Ibadan, Nigeria, where malaria is hyperendemic, to assess how intrauterine exposure to malaria affected infant blood pressure (BP) development. In a local maternity hospital, healthy pregnant women had regular blood films for malaria parasites from booking to delivery. Growth and BP were measured on 318 babies, all followed from birth to 3 and 12 months. Main outcomes were standardized measures of anthropometry and change in BP to 1 year. Babies exposed to maternal malaria were globally smaller at birth, and boys remained smaller at 3 months and 1 year. Change in systolic BP (SBP) during the year was greater in boys than in girls (20.9 versus 15.7 mm Hg; P=0.002) but greater in girls exposed to maternal malaria (18.7 versus 12.7 mm Hg; 95% confidence interval, 1-11 mm Hg; P=0.02). Eleven percent of boys (greater than twice than expected) had a SBP ≥95th percentile (hypertensive, US criteria), of whom 68% had maternal malaria exposure. On regression analysis (β coefficients, mm Hg), sex (boys>girls; β=4.4; 95% confidence interval, 1.1-7.7; P=0.01), maternal malaria exposure (3.64; 0.3-6.9; P=0.03), and weight change (2.4; 0.98-3.8/1 standard deviation score; P=0.001) all independently increased SBP change to 1 year, whereas increase in length decreased SBP (−1.98; −3.6 to −0.40). In conclusion, malaria-exposed boys had excess hypertension, whereas malariaexposed girls a greater increase in SBP. Intrauterine exposure to malaria had sex-dependent effects on BP, independent of infant growth. Because infant-child-adult BP tracking is powerful, a malarial effect may contribute to the African burden of hypertension. (Hypertension. 2014;63:167-172.)

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“…54 Four papers from Southern Africa were from the same cohort but presented data on BP at different ages of follow-up. [46][47][48][49] Four papers reported results in neonates (0-28 days), 41,43,44,51 four in children (1-9 years), 39,40,49,55 four in adolescents (10-19 years) 42,47,48,54 and four in both children and adolescents. 45,46,52,53 The papers were published between 1989 and 2016.…”

Section: Resultsmentioning

confidence: 99%

Is birth weight associated with blood pressure among African children and adolescents? A systematic review

Lule

Elliott

Smeeth

et al. 2018

J Dev Orig Health Dis

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We conducted a review of the evidence on the relationship between birth weight and BP among African children and adolescents. Medline, EMBASE, Global Health and Web of Science databases were searched for publications to October 2016. Papers reporting the relationship between birth weight and BP among African children and adolescents were assessed. Bibliographies were searched for further relevant publications. Selected papers were summarized following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. In total, 16 papers from 13 studies conducted in nine African countries (Nigeria, Republic of Seychelles, Gambia, Democratic Republic of Congo, Cameroon, South Africa, Algeria, Zimbabwe and Angola) were reviewed. Eight studies were cohorts, while five were cross-sectional. The relationship between birth weight and later BP varied with age of the participants. Studies in neonates showed a consistently positive association, while predominantly inverse associations were seen among children, and studies in adolescents were inconsistent. Based on the limited number of studies identified, the relationship between birth weight and later BP may vary with age in African children and adolescents. Not all studies adequately controlled for confounding, notably gender or age. Whether the inverse relationship between birth weight and BP in later life observed in Western settings is also seen in Africa remains unclear.

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Maternal Malaria, Birth Size and Blood Pressure in Nigerian Newborns: Insights into the Developmental Origins of Hypertension from the Ibadan Growth Cohort

Cited by 15 publications

References 41 publications

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

The Impact of Malaria in Pregnancy on Changes in Blood Pressure in Children During Their First Year of Life

Is birth weight associated with blood pressure among African children and adolescents? A systematic review

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