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Winterbone, Mark S.; Sampson, Mike; Saha, Shikha; Hughes, Jackie C.; Hughes, David A.

doi:10.1186/1475-2840-6-8

Cited by 43 publications

(16 citation statements)

References 32 publications

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“…All studies involved patients diagnosed with T2DM (n = 1430) and were conducted mainly in Iran (n = 9 trials) [ 25 , 32 – 34 , 38 , 41 , 43 , 44 , 48 , 51 ]; followed by the United Kingdom (n = 4) [ 42 , 49 , 52 , 53 ] and the United States of America (n = 3) [ 28 , 29 , 47 ]. Evaluated treatments comprised: vitamin B (n = 1 study) [ 25 ], vitamin C (n = 10) [ 26 , 27 , 29 , 34 , 37 , 38 , 40 – 42 , 50 ]; vitamin D (n = 7) [ 30 , 35 , 43 , 44 , 48 , 49 , 53 , 55 ]; vitamin E (n = 12) [ 28 , 32 – 34 , 36 , 39 , 45 – 47 , 51 , 52 , 54 ], and a mixture of vitamins B, C and E (n = 1) [ 31 ]. In four of these trials (13.3%), vitamins were delivered by food fortification (oil or yogurt) [ 32 , 44 , 48 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

Balbi

Tonin

Mendes

et al. 2018

Diabetol Metab Syndr

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BackgroundVitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients.MethodsWe performed a systematic review with meta-analyses. Electronic searches were conducted in PubMed, Scopus, and Web of Science (December 2017). Randomized controlled trials evaluating the effect of any vitamin or vitamin complex supplementation on antioxidant status as primary outcome were included. The outcomes considered were: reduction of malondialdehyde (MDA); augmentation of glutathione peroxidase (GPx); changes in total antioxidant capacity (TAC), enhance in superoxide dismutase enzyme—SOD, and thiobarbituric acid reactive substances (TBARS). Outcomes of glycemic control were also evaluated. Pairwise meta-analyses were performed using software Review Manager 5.3.ResultsThirty trials fulfilled the inclusion criteria, but only 12 could be included in the meta-analyses of antioxidant outcomes. The most commonly studied vitamins were B, C, D and E. Vitamin E was related to significant reduction of blood glucose as well as glycated hemoglobin compared to placebo, while both vitamins C and E were mainly associated with reducing MDA and TBARS and elevating GPx, SOD and TAC, compared to placebo. However, outcome reports in this field are still inconsistent (e.g. because of a lack of standard measures).ConclusionsSupplementation of vitamin E may be a valuable strategy for controlling diabetes complications and enhancing antioxidant capacity. The effects of other micronutrients should be further investigated in larger and well-designed trials to properly place these complementary therapies in clinical practice.Electronic supplementary materialThe online version of this article (10.1186/s13098-018-0318-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…The meta-analyses of the glycemic control parameters (17 included trials obtained from 18 articles) are shown in Figs. 3 , 4 [ 28 – 30 , 33 , 35 – 39 , 43 , 44 , 46 – 49 , 52 , 53 , 55 ]. No statistical differences were observed in subgroup analyses comparing vitamins C or D with placebo.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

Balbi

Tonin

Mendes

et al. 2018

Diabetol Metab Syndr

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“…STZ induced diabetes animals produced systolic and diastolic dysfunction [ 25 ]. Diabetic control showed reduced systolic blood pressure, diastolic blood pressure, end diastolic blood pressure, and mean arterial blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Activity ofPongamia pinnatain Streptozotocin-Nicotinamide Induced Diabetic Rats

Badole¹,

Chaudhari²,

Jangam³

et al. 2015

BioMed Research International

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Pongamia pinnata (L.) Pierre has been used in traditional medicine for the treatment for diabetes and metabolic disorder. The aim of this study was to investigate the effect of petroleum ether extract of the stem bark of P. pinnata (known as PPSB-PEE) on cardiomyopathy in diabetic rats. Diabetes was induced in overnight fasted Sprague-Dawley rats by using injection of streptozotocin (55 mg/kg, i.p.). Nicotinamide (100 mg/kg, i.p.) was administered 20 min before administration of streptozotocin. Rats were divided into group I: nondiabetic, group II: diabetic control (tween 80, 2%; 10 mL/kg, p.o.) as vehicle, and group III: PPSB-PEE (100 mg/kg, p.o.). The blood glucose level, ECG, hemodynamic parameters, cardiotoxic and antioxidant biomarkers, and histology of heart were carried out after 4 months after STZ with nicotinamide injection. PPSB-PEE treatment improved the electrocardiographic, hemodynamic changes; LV contractile function; biological markers; oxidative stress parameters; and histological changes in STZ induced diabetic rats. PPSB-PEE (100 mg/kg, p.o.) decreased blood glucose level, improved electrocardiographic parameters (QRS, QT, and QTc intervals) and hemodynamic parameters (SBP, DBP, EDP, max dP/dt, contractility index, and heart rate), controlled levels of cardiac biomarkers (CK-MB, LDH, and AST), and improved oxidative stress (SOD, MDA, and GSH) in diabetic rats. PPSB-PEE is a promising remedy against cardiomyopathy in diabetic rats.

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“…Although high plasma vitamin E is linked to better cognitive performance [32] there are still some studies that report some disadvantages [82,83,84,85,86,87,88,89]. For instance, the factors that may be involved with the intestinal absorption of vitamin E are not accurately available [82].…”

Section: Vitamin Ementioning

confidence: 99%

“…For instance, the pro-oxidative effects of high dose of vitamin E are linked with increased mortality [85] and incidents of heart failure [84,85]; α- and γ-tocopherol have pro-oxidant activity toward HDL (high density lipoprotein) [86,87] and α-tocopherols on type 2 diabetes patients, with respect to acute hyperglycaemia [88]. Clinical studies that involve vitamin E supplements also found that tocopherol could facilitate the formation of free radicals and this pro-oxidant effect may impact the increase in fatal myocardial infarctions [85,89].…”

Section: Vitamin Ementioning

confidence: 99%

Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease

Adalier

Parker

2016

Antioxidants

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Alzheimer’s disease (AD) is a growing epidemic and currently there is no cure for the disease. The disease has a detrimental effect on families and will strain the economy and health care systems of countries worldwide. The paper provides a literature review on a few ongoing possible antioxidant therapy treatments for the disease. The paper highlights use of vitamin E, turmeric and saffron for an alternative antioxidant therapy approach. Clinical studies report their therapeutic abilities as protective agents for nerve cells against free radical damage, moderating acetylcholinesterase (AChE) activity and reducing neurodegeneration, which are found as key factors in Alzheimer’s. The paper suggests that future research, with more clinical trials focused on more natural approaches and their benefits for AD treatment could be worthwhile.

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Abstract: Background: As a part of a larger study investigating the effects of α-tocopherol on gene expression in type 2 diabetics we observed a pro-oxidant effect of α-tocopherol which we believe may be useful in interpreting outcomes of large intervention trials of α-tocopherol.

Cited by 43 publications

References 32 publications

Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

Cardioprotective Activity ofPongamia pinnatain Streptozotocin-Nicotinamide Induced Diabetic Rats

Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease

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