858 Helicobacter pylori-Negative Chronic Active Gastritis: A New Entity or the Result of Widespread Acid Inhibition?

Genta, Robert M.; Schuler, Christopher M.; Lash, Richard H.

doi:10.1016/s0016-5085(08)60583-1

Cited by 5 publications

(4 citation statements)

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“…This phenomenon of chronic active gastritis with no detectable H. pylori seems to be increasingly common in the Western world, and some possible explanations for this phenomenon include antibiotic therapy for the treatment of other infections, the widespread use of PPIs, and inadequate sampling or suboptimal staining techniques as suggested previously [23][24][25] . However, we used multiple diagnostic tests in the present study to avoid false H. pylori-negative results because no single test is considered the gold standard for the diagnosis of H. pylori infection.…”

Section: Discussionmentioning

confidence: 97%

Histological and endoscopic features of the stomachs of patients with Chagas disease in the era of Helicobacter pylori

Fonseca

Etchebehere

Queiroz

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 97%

Histological and endoscopic features of the stomachs of patients with Chagas disease in the era of Helicobacter pylori

Fonseca

Etchebehere

Queiroz

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…Although H. pylori negative chronic active gastritis, which is a subtype of gastritis, is encountered very rarely in a healthy population, it was observed much commonly in UC (30%) and CD patients (70%) [ 26 ]. Therefore, some investigators suggested that the presence of the H. pylori negative chronic active gastritis must be included in the definitive diagnosis of IBD [ 27 28 29 ].…”

Section: Discussionmentioning

confidence: 99%

Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

Baştürk

Artan

Yılmaz

et al. 2018

Pediatr Gastroenterol Hepatol Nutr

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PurposeThe aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences.MethodsThis study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined.ResultsIn our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03).ConclusionThe results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.

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“…We hypothesised that if the majority of cases of Helicobacter ‐negative gastritis were ‘missed’ Helicobacter infections, their prevalence should represent a relatively constant percentage of the H. pylori infections in a population. If, as in a pilot study presented only in abstract form, 82% of all cases of chronic active gastritis show bacteria and 18% do not, this ratio should remain relatively constant across different populations, irrespective of their prevalence of H. pylori , provided that the diagnoses are made by a group of observers who use similar criteria and identical detection methods. This study was designed to test this hypothesis using data generated by a single group of pathologists who examined and diagnosed gastric biopsy specimens from almost one million patients during the past 6 years.…”

Section: Introductionmentioning

confidence: 98%

Helicobacter‐negative gastritis: a distinct entity unrelated to Helicobacter pylori infection

Genta

Sonnenberg

2014

Aliment Pharmacol Ther

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SUMMARY BackgroundHelicobacter-negative gastritis is diagnosed when no organisms are detected in a gastric mucosa with typical features of Helicobacter gastritis (Hp-gastritis). If Helicobacter-negative gastritis consisted mostly of 'missed' Helicobacter infections, its prevalence should represent a constant percentage of these infections in a population, and their clinico-epidemiological features would overlap.

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858 Helicobacter pylori-Negative Chronic Active Gastritis: A New Entity or the Result of Widespread Acid Inhibition?

Cited by 5 publications

References 0 publications

Histological and endoscopic features of the stomachs of patients with Chagas disease in the era of Helicobacter pylori

Histological and endoscopic features of the stomachs of patients with Chagas disease in the era of Helicobacter pylori

Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

Helicobacter‐negative gastritis: a distinct entity unrelated to Helicobacter pylori infection

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