857-860Anti-inflammatory Effect of Magnolol, Isolated from<i>Magnolia officinalis</i>, on A23187-induced Pleurisy in Mice

Wang, Jih‐Pyang; Ho, Tsing-Fen; Chang, Ling‐Chu; Chen, Chien‐Chih

doi:10.1111/j.2042-7158.1995.tb05754.x

Cited by 81 publications

(35 citation statements)

References 17 publications

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“…The oriental anti-inflammatory herb [109], Magnolia officinalis, has long been used in East Asian countries. Its magnolol and honokiol potently inhibit P. acnes and P. granulosum (MIC = 3-4 and 9 lg ml , respectively) with the proven anti-inflammatory effects [110].…”

Section: Subjectively Used Herbsmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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SynopsisAcne vulgaris suppresses an individual's self-confidence by causing distress with regard to physical appearance, which affects a significant number of individuals during puberty and is delineated by adolescence. Several treatments have been introduced to decrease the aesthetic and psychological problems caused by acne. The topical application of therapeutic agents has been found to be more feasible than hormonal treatment and laser therapy. The ingredients in topical acne treatments, particularly herbs and naturally derived compounds, have received considerable interest as they have fewer adverse effects than synthetic agents. Ré suméL'acné vulgaire touche à l'assurance d'un individu en causant une détresse face à son apparence physique. Elle affecte un nombre important d'individus pendant la puberté et est associée à l'adolescence. Plusieurs traitements ont été proposés pour diminuer les problèmes esthétiques et psychologiques causés par l'acné. L'application topique d'agents thérapeutiques a été estimée plus aisée qu'un traitement hormonal et une thérapie laser. Les ingrédients des traitements topiques de l'acné, particulièrement les plantes et les composés naturels dérivés ont suscité un intérêt considérable par leurs moindres effets indésirables que les ingrédients synthé-tiques.

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Section: Subjectively Used Herbsmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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“…This compound has been demonstrated to possess various pharmacological activities, such as anticancer, antibacterial, antioxidative, and anti-inflammatory activities (Wang et al, 1995;Park et al, 2004;Chen et al, 2009;Lee et al, 2009 supercritical carbon dioxide extract (MBSE, containing at least 93% magnolol) is now used as a food supplement in mints and gums to freshen breath (Greenberg et al, 2007). It was presumed that the application of this compound was very safe and had many beneficial effects .…”

Section: Introductionmentioning

confidence: 99%

Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9

Zhu¹,

Ge²,

Liu³

et al. 2012

Xenobiotica

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Abstract1. Human exposure to magnolol can reach a high dose in daily life. Our previous studies indicated that magnolol showed high affinities to several UDP-glucuronosyltransferases (UGTs) This study was designed to examine the in vitro inhibitory effects of magnolol on UGTs, and further to evaluate the possibility of the in vivo inhibition that might happen. 2. Assays with recombinant UGTs and human liver microsomes (HLM) indicated that magnolol (10 µM) can selectively inhibit activities of UGT1A9 and extra-hepatic UGT1A7. Inhibition of magnolol on UGT1A7 followed competitive inhibition mechanism, while the inhibition on UGT1A9 obeyed either competitive or mixed inhibition mechanism, depending on substrates. The K i values for UGT1A7 and 1A9 are all in nanomolar ranges, lower than possible magnolol concentrations in human gut lumen and blood, indicating the in vivo inhibition on these two enzymes would likely occur. 3. In conclusion, UGT1A7 and 1A9 can be strongly inhibited by magnolol, raising the alarm for safe application of magnolol and traditional Chinese medicines containing magnolol. Additionally, given that UGT1A7 is an extrahepatic enzyme, magnolol can serve as a selective UGT1A9 inhibitor that will act as a new useful tool in future hepatic glucuronidation phenotyping.

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“…Hesperidin, as the main compound of Fructus Aurantii, stimulated the gastrointestinal movement (Fang et al, 2009), exhibited antinociceptive activities in the abdominal writhing and hot-plate test (Loscalzo et al, 2011) and showed antiinflammatory properties (Manthey et al, 2001). Naringenin, magnolol and muscone showed anti-inflammatory effects (Hsu et al, 2004;Liang et al, 2010;Park et al, 2004;Tsai et al, 1999;Wang et al, 1995). Anthraquinone derivatives including aloe-emodin, rhein and sennosides also showed anti-inflammatory effects (Ma et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

Liu

Zhang

Gao

et al. 2013

Pharmaceutical Biology

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Context: Currently, famous traditional Chinese medicine formulas have undergone re-evaluation and development in China. Wei-Chang-An-Wan (WCAW) as one of them has been used for treating various gastrointestinal diseases for several decades. The secondary development of WCAW is in progress so as to interpret the effective material basis or find new pharmacological activity. Objective: To evaluate the antinociceptive effect of methanol extract of WCAW (ME) as well as four fractions (P.E., EtOAc, n-BuOH, H 2 O) and obtain information on the correlation between the contents of the fractions and antinociceptive effect. Materials and methods: ME was divided into four parts extracted by petroleum ether, ethyl acetate and n-butanol. Antinociceptive activity was evaluated by three models of acetic acid-induced writhing, formalin and hot-plate test in mice after repetitive administration of ME at 200, 400 or 800 mg/kg, P.E. 132 mg/kg, EtOAc 106 mg/kg, n-BuOH 176 mg/kg and H 2 O 176 mg/kg for six days. The chemical compounds were analyzed by HPLC-ESI-MS. Results: ME at 800 mg/kg inhibited acid-induced writhing by 84.69%, and reduced the licking time of second phase in formalin test by 53.23%. The inhibition rates in acid-induced writhing of P.E., EtOAc, n-BuOH and H 2 O were 27.79, 33.85, 38.97 and 37.69%, respectively, and in formalin test about 50%. They had no effect on the hot-plate test. HPLC-ESI-MS analysis showed that 68 chemical compounds were detected and 41 compounds were identified from ME. Discussion and conclusion: The results obtained herein indicate that WCAW possesses the antinociceptive activity that provides a new aspect in clinical application.

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857-860Anti-inflammatory Effect of Magnolol, Isolated fromMagnolia officinalis, on A23187-induced Pleurisy in Mice

Cited by 81 publications

References 17 publications

Therapeutic agents and herbs in topical application for acne treatment

Therapeutic agents and herbs in topical application for acne treatment

Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

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