825 Complications of initial prostate biopsy in a European randomized screening trial

Heuvel, S. van den; Loeb, Stacy; Zhu, Xudong; Verhagen, Paul C.M.S.; Schröder, F.H.; Bangma, C.H.; Roobol, Monique J.

doi:10.1016/s1569-9056(12)60822-7

Cited by 3 publications

(7 citation statements)

References 19 publications

(24 reference statements)

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“…6,12,19 These risk factors can be considered outdated because they were described under diverse antibiotic prophylaxis schemes, in a scenario where infections were the most frequent complication. 6,9–12,17–20 In this study, BMI, post-voiding residual volume, ethnic group and PSA density were associated with major post-biopsy complications. The post-voiding residual volume and PSA density are both variables related to the prostate enlargement and bladder outlet obstruction.…”

Section: Discussionmentioning

confidence: 55%

“…The frequency of infectious complications, acute urinary retention and bleeding (grouping gross hematuria and rectal bleeding) after the biopsy were annotated and assumed as major complications, following the previously described classification, 17 were reported. Minor complications, such as vasovagal syncope, mild hematuria and hematospermia or transient rectal bleeding were not described.…”

Section: Methodsmentioning

confidence: 99%

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Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

Rodrigues

Muglia

Albuquerque

et al. 2021

Journal of Clinical Urology

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Objective: To identify risk factors for major post-biopsy complications under augmented prophylaxis protocol. The risk factors already described mainly comprise outdated antibiotic prophylaxis protocols. Material and methods: This retrospective cohort study included patients that underwent transrectal ultrasound-guided biopsies, from 2011 to 2016. All patients had received antibiotic prophylaxis with ciprofloxacin and gentamicin. Patients were grouped according to the presence or absence of post-biopsy complications. Demographic variables and possible risk factors based on routine clinical assessment were registered. Correlation tests, univariate and multivariate analyses were used to identify risk factors for post-biopsy complications. Results: Of the 404 patients that were included, 25 (6.2%) presented 27 post-biopsy complications, distributed as follows: acute urinary retention ( n = 14, 3.5%), infections ( n = 11, 2.7%) and hemorrhage ( n = 2, 0.5%). On univariate analysis, patients who presented complications showed higher body mass index and post-voiding residual volumes. Multivariate analysis identified ethnicity and prostate-specific antigen (PSA) density as possible risk factors for biopsy complications. The presence of bacterial resistance identified by rectal swabs did not correlate with the incidence of complications and infections. Conclusions: Non-infectious post-biopsy complications were more frequent than infectious ones in this cohort. Higher post-voiding residual volumes and PSA density, that indicates prostate enlargement, were identified as risk factors and interpreted as secondary to bladder outlet obstruction. The higher body mass index and ethnicity were also identified as risk factors and attributed to the heterogeneity of the patients included. Level of evidence: Not applicable for this multicentre audit.

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Section: Discussionmentioning

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

Rodrigues

Muglia

Albuquerque

et al. 2021

Journal of Clinical Urology

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“…(17,18) In a European study of more than 7,000 prostate biopsies, the most frequent complication was hematospermia, with an incidence of 53.8%. (19) Hematuria (24.3%), significant pain (4.8%), fever (4.1%), and hospital admission (0.7%) were less frequent. (19)…”

Section: Discussionmentioning

confidence: 94%

“…(19) Hematuria (24.3%), significant pain (4.8%), fever (4.1%), and hospital admission (0.7%) were less frequent. (19)…”

Section: Discussionmentioning

confidence: 98%

Optimizing safety and accuracy of prostate biopsy

Jones

Radtke²,

Hadaschik³

et al. 2016

Current Opinion in Urology

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Purpose of review The objective of this article is to examine the safety of prostate biopsy and discuss the emerging role of MRI - ultrasound fusion technology in improving diagnostic accuracy. Recent findings Men undergoing prostate biopsy frequently experience minor complications, including hematospermia, hematuria, and infection. Quinolone-resistant bacteria are a growing concern; thus transperineal access or modification of antibiotic prophylaxis based on local antibiograms is now used to avoid infectious complications. Multiparametric MRI allows visualization of many prostate cancers, and by fusing MRI with realtime ultrasound, a biopsy needle can be directed by a urologist into suspicious regions of interest. Using this new method, detection of clinically significant prostate cancer (csCaP) has increased and the incidence of falsely negative biopsies has decreased. Summary Prostate biopsy is generally a safe procedure, and with attention to local patterns of antibiotic resistance, infectious complications can be minimized. MRI - ultrasound fusion has significantly improved the accuracy of prostate biopsy, allowing tracking and targeting not previously possible.

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“…3,5 Although prostate biopsy is generally considered safe, it can still cause a series of side effects such as bleeding, pain, and infection. 6 Therefore, a noninvasive diagnostic tool for PCa is urgently needed.…”

mentioning

confidence: 99%

Editorial for “A Deep Learning Approach to Diagnostic Classification of Prostate Cancer Using Pathology‐Radiology Fusion”

2021

Magnetic Resonance Imaging

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825 Complications of initial prostate biopsy in a European randomized screening trial

Cited by 3 publications

References 19 publications

Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

Optimizing safety and accuracy of prostate biopsy

Editorial for “A Deep Learning Approach to Diagnostic Classification of Prostate Cancer Using Pathology‐Radiology Fusion”

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