8-Ply Small Intestinal Submucosa Tension-Free Sling:: Spectrum of Postoperative Inflammation

Ho, Khai-Linh V.; Witte, Matthew N.; Bird, Erin T.

doi:10.1097/01.ju.0000098680.60020.32

Cited by 49 publications

(24 citation statements)

References 18 publications

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“…A certain cytotoxicity was noticed concerning the SIS matrix, in addition to its immunogenic nature. Indeed, a series of postoperative inflammatory reactions (Ho et al 2004) preceded the in vitro detection of porcine DNA residues on the commercially available SIS, by specific chromatin staining (Feil et al 2006). These last reports made on this model, confirmed it as an unfavorable substitute for vesical reconstruction.…”

Section: Bladdermentioning

confidence: 86%

Evolution in Tissue Engineering for the Lower Urinary Tract

Bouhout¹,

Ouellet²,

Perron³

et al. 2010

Tissue Engineering

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Section: Bladdermentioning

confidence: 86%

Evolution in Tissue Engineering for the Lower Urinary Tract

Bouhout¹,

Ouellet²,

Perron³

et al. 2010

Tissue Engineering

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“…poly (lactic acid) (PLA) products, including tissue screws, tacks, and suture anchors, as well as systems for meniscus and cartilage repair, are commonly used. Synthetic polyesters degrade by hydrolysis 62 and their degradation rates and mechanical properties can be altered via polymerization techniques [63][64][65] and processing conditions. [66][67][68][69] However, these polymers show poor regulation on cellular activity.…”

Section: Materials For Electrospinningmentioning

confidence: 99%

Next Generation of Electrosprayed Fibers for Tissue Regeneration

Hong

Madihally

2011

Tissue Engineering Part B: Reviews

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Electrospinning is a widely established polymer-processing technology that allows generation of fibers (in nanometer to micrometer size) that can be collected to form nonwoven structures. By choosing suitable process parameters and appropriate solvent systems, fiber size can be controlled. Since the technology allows the possibility of tailoring the mechanical properties and biological properties, there has been a significant effort to adapt the technology in tissue regeneration and drug delivery. This review focuses on recent developments in adapting this technology for tissue regeneration applications. In particular, different configurations of nozzles and collector plates are summarized from the view of cell seeding and distribution. Further developments in obtaining thick layers of tissues and thin layered membranes are discussed. Recent advances in porous structure spatial architecture parameters such as pore size, fiber size, fiber stiffness, and matrix turnover are summarized. In addition, possibility of developing simple three-dimensional models using electrosprayed fibers that can be utilized in routine cell culture studies is described. Tissue EngineeringT issue engineering or regeneration is a multidisciplinary study to restore, maintain, and enhance tissue and organ function. 1 In tissue engineering, biodegradable scaffolds are used to support and guide cells to proliferate, organize, and produce their own extracellular matrix (ECM). Scaffolding material eventually disappears leaving only the necessary healthy tissue in a topologically required form. 2,3 Assembly and maturation of ECM elements is important in determining the biomechanics and the quality of the tissue. For example, collagen provides tensile strength to the tissue, elastic fibers contribute to the elasticity of the tissue, while proteoglycans fills the extracellular space, creating a space for the tissue regulation of growth factors and other interactions. 4 Delicate balance between different matrix elements is necessary to generate healthy tissue. The size and shape of collagen fibers in ECM relies on tissues and organs even in the same species. The shape is cord or tape with a width of 1-20 mm and the collagen fibrils (unit can be observed by electron microscopy) are cylindrical with a diameter ranging from 10 to over 500 nm where cell is attaching and hugging. 5 Obtaining a biodegradable matrix conducive for cell colonization is a fundamental requirement for tissue regeneration. Like ECM, biomimic scaffold should allow cell attachment and migration, enables diffusion of vital cell nutrients, and retains cells. Further, chemical and mechanical properties of scaffold influence cell viability and proliferation. 6 Appropriate pore size and porosity are essential to modulate cell seeding and diffusion. Biodegradability is essential because scaffolds are absorbed and distributed to the nearby tissue, which allows no surgical removal from body. The surface of scaffold is suitable for cell attachment and migration. The mechanical properties...

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“…Theoretically, an implanted ECM should not elicit an immediate or delayed immune response due to its acellular and avascular nature (Allman et al 2001, Ho et al 2004, Sandusky et al 1992). However, we know that elimination of all nuclear materials and cell membrane products is almost impossible despite extensive measures taken during the decellularisation process.…”

Section: Immunogenic Response After Implantationmentioning

confidence: 99%