8-O-β-D-Glucopyranosyl-2-methylchromone, a new chromone glycoside from the Tibetan medicine plant of Swertia punicea Hemsl

Abstract

A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ESI-MS, 1D and 2D NMR spectroscopic data and comparison with data reported in the literature. In vitro test, all compounds were evaluated for their anti-inflammatory activity through determination of nitric oxide (NO) production. Compounds 1-2 were evaluated for cytotoxic activities against three human cancer cell lines (HeLa, MDA-MB-231 and A375) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. Furthermore, the chemotaxonomic significance of these compounds has also been described.

Diverse Flavonoids from the Roots of Indigofera stachyodes

“…After the acid hydrolysis of compound 1 , the released sugar was determined to be D‐glucose by comparison on thin‐layer chromatography (TLC) with a standard sample ($${{\left[{\rm \alpha }\right]}_{{\rm D}}^{25}}$$ =+47.5, MeOH) [8] . The D‐glucose unit was determined to have β ‐configuration from the 3 J H1′′,H2′′ coupling constant (7.8).…”

“…After the acid hydrolysis of compound 1, the released sugar was determined to be D-glucose by comparison on thin-layer chromatography (TLC) with a standard sample ( a ½ � 25 D = + 47.5, MeOH). [8] The Dglucose unit was determined to have β-configuration Table 1. 1 H (600 MHz) and 13 C NMR (150 MHz) data for compounds 1 and 2.…”

Swertia L.: A comprehensive review of its genetic relationship, chemical compositions, pharmacological effects, toxicities, and applications

“…Figure 7 (5) (Mou et al, 2022) induced liver injury and inflammation mainly by interfering with the nuclear factor erythroid 2-related factor 2 (Nrf2)/hemeoxygenase-1 (HO-1) pathway . signaling pathway and increasing bile acid excretion (Shi et al, 2022).…”