8-Hydroxy-2′-deoxyguanosine expression predicts hepatocellular carcinoma outcome

Li, Shengmian; Wang, Xiaoling; Wu, Yongyang; Zhang, Huijing; Zhang, Lan; Wang, Cuiju; Zhang, Ruixing; Guo, Zhanjun

doi:10.3892/ol.2011.477

Cited by 18 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Miyake et al [17] have proven the association between 8-OHdG expression and tumor size, clinical stage, and venous invasion in renal cell carcinoma progress, and Li et al have also proven the association between 8-OHdG expression and postoperative hepatocellular carcinoma survival [12]. Consistent with previous studies, we found the prognosis value of 8-OHdG for esophageal cancer.…”

Section: Discussionsupporting

confidence: 91%

“…Levels of 8-OHdG were measured as described previously [11,12]; the 8-OHdG-stained esophageal epithelial cells in 10 different random fields at a magnification of ×400 were counted independently by 2 pathologists. The percentage of positive cells versus total cells that we defined as 8-OHdG label index (LI) in each field was calculated and graded with semiquantitative methods as follows: grade "low" is defined as the percentage of positive cells staining no more than 50%, and grade "high" as the percentage greater than 50% (Fig.…”

Section: Measurements Of 8-ohdg Levels In Esophageal Cancerous Tissuesmentioning

confidence: 99%

See 1 more Smart Citation

8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

Zhao

Wang

et al. 2014

Annals of Diagnostic Pathology

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Section: Measurements Of 8-ohdg Levels In Esophageal Cancerous Tissuesmentioning

confidence: 99%

8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

Zhao

Wang

et al. 2014

Annals of Diagnostic Pathology

Self Cite

View full text Add to dashboard Cite

“…A previous study has demonstrated that oxidative stress of mtDNA is associated with the post-operative survival of patients with HCC (18). In the present study, the results demonstrated that ROS levels were associated with the carcinogenesis of HCC and the post-operative survival of HCC patients.…”

Section: Factorssupporting

confidence: 73%

Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma

Zhao

et al. 2015

Oncology Letters

Self Cite

View full text Add to dashboard Cite

Abstract. In the present study, two oxidative stress parameters, reactive oxygen species (ROS) and mitochondrial respiratory complex II, were evaluated in the mitochondria of hepatocellular carcinoma (HCC) cells to determine the association between these parameters and the carcinogenesis and clinical outcome of HCC. High levels of ROS and low levels of complex II were found to be associated with reduced post-operative survival in HCC patients using the log-rank test. Furthermore, multivariate analysis confirmed that the levels of ROS [relative risk (RR)=2.867; 95% confidence interval (CI), 1.062-7.737; P=0.038] and complex II (RR=5.422; 95% CI, 1.273-23.088; P=0.022) were independent predictors for the survival of patients with HCC. Therefore, the analysis of ROS and complex II levels may provide a useful research and therapeutic tool for the prediction of HCC prognosis and treatment.

show abstract

“…The percentage of positively stained cells was calculated, which was termed the 8-OHdG label index (LI), in each field and graded as follow: low, LI <50%; high, LI >50% [15].…”

Section: -8-hydroxydeoxyguanosinementioning

confidence: 99%

Expression of Glypican-3(gpc-3) and 8-Hydroxydeoxyguanosine (8-Ohdg) in Chronic Hepatitis C and Relationship With Hepatocellular Carcinoma

El-Alfy

ElKashishy

George

et al. 2017

Zagazig University Medical Journal

View full text Add to dashboard Cite

Background: In Egypt, hepatocellular carcinoma (HCC) is the second most common cancer in men and the 6th most common cancer in women. Egypt has the highest prevalence of HCV in the world and the prevalence of HCC is increasing in the last years. Glypican-3 (GPC-3), a member of heparin sulfate proteoglycans, plays a role in cell growth, differentiation, and migration. 8-Hydroxydeoxyguanosine (8-OHdG) is an oxidatively modified promutagenic DNA that is produced by oxygen radicals and is recognized as a useful marker in estimating DNA damage induced by oxidative stress. The aim: This study was conducted to evaluate glypican-3 (GPC-3) and 8-hydroxydeoxyguanosine (8-OHdG) expression in chronic hepatitis C and hepatocellular carcinoma as predictive markers for hepatocellular carcinoma. Methods: 75 cases (50 cases of chronic hepatitis C and 25 of hepatocellular carcinoma) were examined immunohistochemically using antibodies against Glypican-3 (GPC-3) and 8-Hydroxydeoxyguanosine (8-OHdG). Results: Glypican-3 expression was observed in 18 % of cases of chronic hepatitis C, all positive cases were in the high grade, while none of low grade chronic hepatitis cases showed glypican-3 positivity. Glypican-3 expression was observed in 88% of cases of HCC. High 8-OHdG index was observed in 72.4% of cases of low grade chronic hepatitis and 95.2% of cases of high grade chronic hepatitis, while low index was observed in 27.6% of low grade chronic hepatitis and in 4.8% of cases of high grade chronic hepatitis. There was a statistically significant difference in 8-OHdG expression between low and high grade chronic hepatitis (P=0.05). There was no statistically significant difference in glypican-3 and 8-OHdG expression between different grades of HCC. Conclusion: Glypican-3 was expressed in 18% of cases of chronic hepatitis C, 35.1% of cirrhosis and 36.4% of cirrhosis adjacent to hepatocellular carcinoma. Our results suggest that GPC-3 may be considered as an early marker of liver carcinogenesis. 8-OHdG was observed in all cases of chronic hepatitis C, with high labeling index in 82% of cases and low index in 18% of cases. Our study showed high labeling index of 8-OHdG in 52% of cases of HCC. These results indicate that oxidative DNA damage is common in livers with chronic injury suggesting a possible link between chronic inflammation and hepatocarcinogenesis.

show abstract

8-Hydroxy-2′-deoxyguanosine expression predicts hepatocellular carcinoma outcome

Cited by 18 publications

References 28 publications

8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma

Expression of Glypican-3(gpc-3) and 8-Hydroxydeoxyguanosine (8-Ohdg) in Chronic Hepatitis C and Relationship With Hepatocellular Carcinoma

Contact Info

Product

Resources

About