8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

He, Hong-Tao; Zhao, Yufei; Wang, Na; Zhang, Lan; Wang, Cuiju

doi:10.1016/j.anndiagpath.2014.08.008

Cited by 18 publications

(17 citation statements)

References 15 publications

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“…13 The expression of 8-OHdG was higher in human esophageal cancer tissue than in normal epithelium, 5 and predictive of the disease outcome. 14 The expression level of 8-OHdG was also prognostic in patients with non-small-cell lung and urinary bladder cancer. 6,15 In skin, 8-OHdG expression is induced by UVR in normal human epidermis 16 and increased in arsenic-induced BD.…”

Section: Discussionmentioning

confidence: 98%

“…8‐OHdG, an oxidized form of deoxyguanosine nucleoside, is produced by oxidative damage to DNA and can be detected by immunohistochemical analysis . The expression of 8‐OHdG was higher in human esophageal cancer tissue than in normal epithelium, and predictive of the disease outcome . The expression level of 8‐OHdG was also prognostic in patients with non‐small‐cell lung and urinary bladder cancer .…”

Section: Discussionmentioning

confidence: 99%

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Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma

Yoshifuku

Fujii

Kanekura

2018

The Journal of Dermatology

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Detailed mechanisms on the effect of oxidative stress (OS), an etiological factor involved in photocarcinogenesis, remain to be fully elucidated. We used immunohistochemical methods to study OS in the DNA, protein and lipids of patients with actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC). Between January 2009 and December 2014, we treated 230 patients; 79 had AK, 61 had (BD) and 90 had cutaneous SCC; 28 healthy subjects served as the normal controls. OS on DNA, protein and lipids was assessed by the expression of 8-hydroxydeoxyguanosine (8-OHdG), dityrosine (DT) and malondialdehyde (MDA), respectively. 8-OHdG was significantly overexpressed in AK and BD lesions compared with surrounding non-lesional tissue, SCC lesions and the healthy controls. DT was more highly expressed in AK, BD and SCC than in the controls. There was no significant difference among AK, BD and SCC. The expression of MDA was higher in AK, BD and SCC lesions than the controls; SCC showed the highest expression. Our observations suggest that DNA oxidation plays an important role in the early stage of carcinogenesis, that protein oxidation is involved in all stages of carcinogenesis and that lipid oxidation is strongly implicated in the late stages of carcinogenesis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma

Yoshifuku

Fujii

Kanekura

2018

The Journal of Dermatology

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“…8-Hydroxy-2′-deoxyguanosine (8-OHdG), a product of DNA base modification produced by the oxidation of deoxyguanosine, is widely accepted as a marker of oxidative DNA damage and oxidative stress [16, 17]. Elevated levels of 8-OHdG in the urine, plasma, and serum samples of patients with a range of cancer types have previously been reported [18–22]. Similarly, urinary 8-OHdG levels were higher in patients with hypoactive thyroid nodules (single and multiple) diagnosed with Graves' disease, toxic multinodular goiter, and Hashimoto's thyroiditis than those in the controls [23].…”

Section: Introductionmentioning

confidence: 99%

Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer

Dönmez-Altuntaş

Bayram

Bıtgen

et al. 2017

International Journal of Endocrinology

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Thyroid nodules are a common clinical problem worldwide. Although thyroid cancer accounts for a small percentage of thyroid nodules, the majority are benign. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) levels are a marker of oxidative stress and play a key role in the initiation and development of a range of diseases and cancer types. This study evaluates cytokinesis-block micronucleus cytome (CBMN-cyt) assay parameters and plasma 8-OHdG levels and their association with thyroid nodule size and thyroid hormones in patients with multinodular goiter. The study included 32 patients with multinodular goiter and 18 age- and sex-matched healthy controls. CBMN-cyt assay parameters in peripheral blood lymphocytes of patients with multinodular goiter and controls were evaluated, and plasma 8-OHdG levels were measured. The micronucleus (MN) frequency (chromosomal DNA damage), apoptotic and necrotic cells (cytotoxicity), and plasma 8-OHdG levels (oxidative DNA damage) were significantly higher among patients with multinodular goiter. Our study is the first report of increased chromosomal and oxidative DNA damage in patients with multinodular goiter, which may predict an increased risk of thyroid cancer in these patients. MN frequency and plasma 8-OHdG levels may be markers of the carcinogenic potential of multinodular goiters and could be used for early detection of different cancer types, including thyroid cancer.

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“…When it attacks DNA, 8-hydroxydeoxyguanosine (8-OHdG) can be formed. Tissue expression of 8-OHdG and its serum concentrations are associated with the prognosis of several carcinomas, including ovarian cancer, breast cancer, colorectal cancer, cutaneous melanoma, non-small-cell lung cancer, diffuse large B-cell lymphoma and esophageal cancer [ 7 – 13 ]. In colorectal carcinomas, immunohistochemical expression levels of 8-OHdG and nitrotyrosine are significantly higher in malignant tissues compared with adenomas or non-tumorous tissues of the colon [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer

2015

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BackgroundOxidative stress is a widely seen phenomenon in several carcinomas. Increasing evidence also suggests that it has a significant role in the development of epithelial ovarian carcinoma (EOC). 8-Hydroxydeoxyguanosine (8-OHdG) is one of the main indicators of oxidative stress and increased expression of 8-OHdG has previously been seen in EOC. DJ-1 is an oncoprotein connected to oxidative stress regulation, but its role in ovarian cancer is not well known. We investigated redox status in different histotypes of EOC by measuring serum 8-OHdG and DJ-1 concentrations and their associations with known prognostic factors.MethodsSerum samples from newly diagnosed EOC patients were collected in 1996–2009 and stored at the Department of Obstetrics and Gynecology, Oulu University Hospital. Serum 8-OHdG and DJ-1 levels were measured by using commercially available ELISA kits. Clinical data was gathered retrospectively from the patients` files. Results were analyzed by using SPSS software.ResultsIn total, 112 patient samples were analyzed (38 serous, 20 mucinous, 34 endometrioid and 20 clear-cell). High serum 8-OHdG levels were associated with poor overall survival (OS) (p = 0.019), poor disease-free survival (DFS) (p = 0.020), platinum resistance (p = 0.002), serous histology versus other (p = 0.033), stage III–IV versus I–II (p = 0.009) and suboptimal surgical outcome (p = 0.012). Regarding histotypes, in the endometrioid EOC group in particular, serum 8-OHdG levels were significantly associated with poor DFS (p = 0.005), suboptimal surgical outcome (p = 0.025), and platinum resistance (p = 0.007). The prognostic significance of 8-OHdG in patients with endometrioid cancer in terms of DFS was confirmed in Cox regression analysis. High DJ-1 levels were associated with high histological grade (p = 0.029) and nonsignificantly associated with serous histology vs. other histology (p = 0.089).ConclusionsAn elevated serum 8-OHdG level is a significant predictor of poor prognosis, especially in cases of the endometrioid subtype of ovarian carcinoma. High 8-OHdG levels are associated with all traditional factors of poor prognosis in ovarian cancer and they also predict earlier development of platinum resistance. These results could be valuable when deciding the primary treatment mode for EOC patients.

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8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

Cited by 18 publications

References 15 publications

Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma

Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma

Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer

Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer

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