794 the Value of 11c-Acetate Pet for Lymph Node Staging in Patients With Newly Diagnosed Prostate Cancer – Results of a Prospective Study

Schumacher, Douglas; Sørensen, Jens Benn; E, Brekkan; Wassberg, Cecilia; Malmström, Per Uno

doi:10.1016/s1569-9056(09)60782-x

Cited by 2 publications

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“…The remaining 66 citations were evaluated in more detail; 42 studies were excluded at this stage for being letters to editors, case reports, narrative review articles, or due to incomplete data. Finally, 24 studies were included in the systematic review . Table shows the characteristics of included studies .…”

Section: Resultsmentioning

confidence: 99%

“… reported sensitivity of lymph node staging with 11 C‐acetate with pooled sensitivity of 73 (54–88)% (I 2 = 71%). Three studies reported specificity of lymph node staging with 11 C‐acetate with resulting pooled specificity of 79 (72–86)% (I 2 = 78.3%).…”

Section: Resultsmentioning

confidence: 99%

“… reported that 11 C‐acetate PET/CT could detect lymph node metastasis not identified by conventional imaging and can be used as a complementary imaging method. False positive results have also been reported with resulting sub‐optimal specificity of 79 (72–86) %.…”

Section: Discussionmentioning

confidence: 99%

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

et al. 2013

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• To review the literature on the application of 11 C-acetate positron-emission tomography (PET) imaging in prostate cancer.• We systematically reviewed the available literature and presented the results in meta-analysis format.• PubMed, SCOPUS, ISI web of knowledge, Science Direct, Springer, and Google Scholar were searched with 'Acetate AND PET AND Prostate' as keywords.• All studies that evaluated accuracy of 11 C-acetate imaging in primary or recurrent prostate cancer were included, if enough data could be extracted for calculation of sensitivity and/or specificity.• In all, 23 studies were included in the study. For evaluation of primary tumour, pooled sensitivity was 75.1 (69.8-79.8)% and specificity was 75.8 (72.4-78.9)%. • For detection of recurrence, sensitivity was 64 (59-69)% and specificity was 93 (83-98)%. Sensitivity for recurrence detection was higher in post-surgical vs post-radiotherapy patients and in patients with PSA at relapse of >1 ng/mL. • Studies using PET/computed tomography vs PET also showed higher sensitivity for detection of recurrence.• Imaging with 11 C-acetate PET can be useful in patients with prostate cancer. This is especially true for evaluation of patients at PSA relapse, although the sensitivity is overall low.• For primary tumour evaluation (localisation of tumour in the prostate and differentiation of malignant from benign lesions), 11 C-acetate is of limited value due to low sensitivity and specificity.• Due to the poor quality of the included studies, the results should be interpreted with caution and further high-quality studies are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

et al. 2013

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[F18]-fluoroethylcholine combined in-line PET-CT scan for detection of lymph-node metastasis in high risk prostate cancer patients prior to radical prostatectomy: Preliminary results from a prospective histology-based study

Steuber

Schlomm

Heinzer

et al. 2010

European Journal of Cancer

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794 the Value of 11c-Acetate Pet for Lymph Node Staging in Patients With Newly Diagnosed Prostate Cancer – Results of a Prospective Study

Cited by 2 publications

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

[F18]-fluoroethylcholine combined in-line PET-CT scan for detection of lymph-node metastasis in high risk prostate cancer patients prior to radical prostatectomy: Preliminary results from a prospective histology-based study

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794 the Value of 11c-Acetate Pet for Lymph Node Staging in Patients With Newly Diagnosed Prostate Cancer – Results of a Prospective Study

Cited by 2 publications

References 0 publications

Application of 11C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

Application of 11C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

[F18]-fluoroethylcholine combined in-line PET-CT scan for detection of lymph-node metastasis in high risk prostate cancer patients prior to radical prostatectomy: Preliminary results from a prospective histology-based study

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature