“…Given the significant interest of a tracer to estimate alterations of glucose uptake in vivo, numerous researchers have tried for many years to develop glucose molecules labelled with a radioactive atom which is a pure -emitter, such as iodine 123, and which could be used routinely in Single Photon Emission Computed Tomography (SPECT), in all Nuclear Medicine centers (Kloster et al, 1983a(Kloster et al, , 1983bGoodman et al, 1981aGoodman et al, , 1981bLutz et al, 1991;Magata et al, 1992;Koumanov et al, 1997aKoumanov et al, , 1997bPerret et al, 2004). [ 123 I]-6-deoxy-6-iodo-D-glucose (6DIG) was first synthetized by Wassenar and colleagues, but the biological evaluation was limited to tumor uptake and not evaluated further (Wassenaar et al, 1973).…”