A synthesis of 4-deoxy-4-iodo-D-glucose suitable for radiolabelling.

The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-standard tracer of glucose uptake, 2-deoxy-D-glucose. None of these molecules had the same biological behavior than 2-deoxy-D-glucose. Therefore, these compounds cannot be considered as tracers of glucose uptake.

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Biological studies of radiolabeled glucose analogues iodinated in positions 3, 4 or 6

Perret

Ghezzi

Ogier

et al. 2004

Nuclear Medicine and Biology

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Procurement of 2-deoxy-2-iodo-d-glucose (2-DIG)

Morin

2006

Tetrahedron Letters

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Radiosynthesis and in vitro stability evaluation of various radioiodine-labelled β-iodoalkylether prosthetic groups linked to model compounds

Rossouw

Coenen

2003

Nuclear Medicine and Biology

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A synthesis of 4-deoxy-4-iodo-D-glucose suitable for radiolabelling.

Abstract: A preparation of a D‐glucose analogue in which the 4‐hydroxyl group can be replaced by radioactive iodine is presented. © 1997 John Wiley & Sons, Ltd.

Cited by 3 publications

References 15 publications

Biological studies of radiolabeled glucose analogues iodinated in positions 3, 4 or 6

Biological studies of radiolabeled glucose analogues iodinated in positions 3, 4 or 6

Procurement of 2-deoxy-2-iodo-d-glucose (2-DIG)

Radiosynthesis and in vitro stability evaluation of various radioiodine-labelled β-iodoalkylether prosthetic groups linked to model compounds

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