735 Association between modifiable lifestyle factors and inflammatory markers in patients with metabolic syndrome

Abstract

There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. Recent studies have shown a relationship between inflammatory markers and modifiable lifestyle factors including fitness, diet, exercise and smoking. We carried out a cross-sectional study of 195 patients with metabolic syndrome. Data on nutritional intake, physical activity level and smoking habits were collected through a questionnaire. Weight and body composition were determined and C-reactive protein and interluekin-6 concentrations were measured. C-reactive protein level had a significant association with body mass index (r = 0.18), adiposity (r = 0.23), smoking (r = 0.20), carbohydrate intake (r = 0.19) and saturated fatty acid (r = 0.20). Interluekin-6 concentration was significantly correlated with dietary carbohydrate (r = 0.15), saturated fatty acid (r = 0.15) and glycaemic load (r = 0.15). No association was observed between physical activity level and inflammatory markers.

Association between a Healthy Lifestyle Score and inflammatory markers among Puerto Rican adults

“…Consistent with our results, associations between dietary factors and inflammatory markers have been reported by several studies [5, 7, 8, 24–26]. However, not all studies have shown association with CRP [27, 28], similar to our findings.…”

“…Our finding of the independent association between smoking and IL-6 and TNF-α is substantially supported by the literature [13, 24, 25]. The lack of the association between smoking and CRP may be due to the sequence of the tobacco cascade operation (smoking increases serum concentration of IL-6 and that leads to raised CRP concentration [26]), or timing of the smoking cessation resulting in a delayed decrease of CRP [25]. …”

“…Although having higher socioeconomic and educational status can help support a healthy lifestyle environment, in our analysis the HLS remained significantly associated with inflammatory markers even after adjusting for such factors. Most previous studies on inflammation limited their analyses to individual risk factors, rather than the combined effects of multiple lifestyle behaviors [24–26]. It is thus difficult to compare our HLS results with the existing literature.…”

“…The evidence for physical activity and inflammation is inconsistent; while some studies have reported an association with CRP and IL-6 independent of BMI [10, 11, 29], others found no association or the association was null when adjusted for adiposity markers [24, 26, 30]. Furthermore, we found that IL-6 was associated individually with physical activity and sedentary behavior, and with social support, but that these associations were attenuated when adjusted for the other components of the HLS, suggesting that they were not independent of the other lifestyles behaviors.…”

Effect of zinc supplementation on serum zinc and calcium levels in postmenopausal osteoporotic women in Tabriz, Islamic Republic of Iran

“…In addition, 3-day 24-hour food recall of subjects, including 2 weekdays and 1 weekend day, were collected at baseline and after 60 days to estimate dietary intake of calcium and zinc [13]. The cut-offs for adequate intake of zinc and calcium was defined as 8-40 mg/dL and 1000-2000 mg/dL, respectively [14].…”