Epidemiology of interleukin-6: the 30-year follow-up of the 1982 Pelotas (Brazil) birth cohort study

Santos, Francine Silva dos; Oliveira, Isabel; Mintem, Gicele Costa; Horta, Bernardo Lessa; Gigante, Denise Petrucci

doi:10.1080/03014460.2021.1998619

Annals of Human Biology

2021

DOI: 10.1080/03014460.2021.1998619

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Epidemiology of interleukin-6: the 30-year follow-up of the 1982 Pelotas (Brazil) birth cohort study

Francine Silva dos Santos

Isabel Oliveira

Gicele Costa Mintem

et al.

Abstract: Supplemental Table 1. Comparison between the Pelotas (Brazil) 1982 birth cohort and sample with interleukin-6 data, according to selected variables.Bold font indicates statistically significant difference (p value < 0.05).

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A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women

Razmpoosh,

Safi,

Mazaheri

et al. 2024

BMC Complement Med Ther

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Background Nigella sativa (NS) oil has been found to have advantageous benefits in the management of inflammation and obesity. This study investigated the effect of NS supplementation on blood mRNA expressions and serum levels of IL-1β, IL-6, leptin, and insulin concentrations in overweight/obese women. Methods In a crossover design, participants were randomized to receive either NS supplements(2000 mg/day) or placebo for 2 durations(8 weeks). With between-subject and within-subject components and interactions, a repeated-measure ANOVA model was used considering the treatment, time, and the carryover effects. Cohen’s d(d) was used to measure the magnitude of the effects. Results Forty-six eligible participants were included. NS supplementation significantly reduced the mRNA expressions(d=-0.68, P = 0.03) and serum levels of IL-1β with medium-high effect sizes(d=-1.6, P < 0.001). Significant reductions with large effect sizes were observed in the gene expression and serum levels of IL-6(d=-1.8, d=-0.78, respectively; P < 0.01) and Leptin(d=-1.9, d=-0.89, respectively; P < 0.01, serum leptin P carryover < 0.001). Despite the meaningful carryover effect for serum leptin, results remained significant following the first intervention period analysis(P < 0.001). A significant but low effect size decrease in serum insulin was observed(d=-0.3, P = 0.02). Conclusions The clinical significance of present findings regarding improvements in obesity-related pro-inflammatory markers must be interpreted with caution due to some observed medium-low effect sizes. Trial registration IRCT20180430039475N1 (Date:25/6/2018).

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A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women

Razmpoosh,

Safi,

Mazaheri

et al. 2024

BMC Complement Med Ther

View full text Add to dashboard Cite

show abstract

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Epidemiology of interleukin-6: the 30-year follow-up of the 1982 Pelotas (Brazil) birth cohort study

Abstract: Supplemental Table 1. Comparison between the Pelotas (Brazil) 1982 birth cohort and sample with interleukin-6 data, according to selected variables.Bold font indicates statistically significant difference (p value < 0.05).

Cited by 1 publication

References 54 publications

A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women

A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women

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