707 the Beneficial Effects of Natural Polyphenols on the Dislipidemyand Eye Complications in the Experimental Diabetes Mellitus

The study aims to assess the significance of negative pressure therapy in the treatment of diabetic foot.The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 37 patients with diabetic foot were monitored their clinical course between September 2014 -April 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC ™ -Hartman) in order to apply negative pressure to the wound, while complying with specified settings (negative pressure, time of use of a kit) in accordance with patients' outcome.There were monitored changes in wound size (planimetric and volumetric measurement), their bacterial load and duration of treatment. Healing was obtained in all cases, to an average hospital stay of 27.3 days and 8 days of therapy application.The negative result of microbial cultures was obtained after an average of 6.45 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. Skin grafts were necessary to close the defect in 4 cases. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing.In patients with diabetic foot who were required surgical intervention, the use of negative pressure therapy yielded a significant benefit in the preservation of the affected limb, after minimal excision.The results we obtained throughout our experience recommend use of NPTW technique as indication for abdominal wall surgery in closing abdominal wall defects, compartment syndrome and surgical site infection after prosthetic mesh.

Section: Resultsmentioning

confidence: 99%

Negative Pressure Therapy in the Surgical Treatment of Diabetic Foot

Ciuntu¹,

Vasiluta²,

Negru³

et al. 2017

“…However, studies in pediatric oncology patients showed that this method can be used as an adjuvant in wound healing and closure even in rare pediatric cancers [5].Small and dense LDLc (LDLcholesterol) particles seem to be the marker of a series of anomalies including HDLc (HDL-cholesterol) concentration decrease, apoB concentration increase, insulin sensitivity decrease, and procoagulant changes (PAI-1 increase) [6]. Numerous experimental studies prove the capacity of the vegetal polyphenols to diminish the lipid peroxidation and to reduce the LDL oxidation [7]. The macrophages, T cells and cytokines (Interleukin-1-beta) cooperate in synergy to destroy B cells.…”

Section: Resultsmentioning

confidence: 99%

Negative Pressure Therapy in Wounds Surgical Treatment

Ciuntu¹,

Georgescu²,

Cirdeiu³

et al. 2017

The study aims to assess the significance of negative pressure therapy in the treatment of 1 January 2014 - 31 June 2017. The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 31 patients with various tipe of wounds which were monitored their clinical course between September 2014 - February 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC � -Hartman) in order to apply negative pressure to the wound, while complying with specified settings in accordance with patients� outcome. Healing was obtained in all cases, to an average hospital stay of 30 days and 12 days of therapy application.The negative result of microbial cultures was obtained after an average of 7.55 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing. Evolution was favorable with wound granulation in 95% cases, which allowed surgery under local anesthesia, and defect was covered with skin graft. VAC therapy falls into the last group of treatments by eliminating healing inhibitors. This regenerates the wound in a damp environment and essentially turns an open wound into a closed system.

“…Insulin dependent diabetes mellitus is the result of this action [8]. The expression of proinflammatory cytokines and other mediators, including adhesion molecules, suggests that the inflammatory process may contribute to the vascular disease in diabetes mellitus [9]. Numerous experimental studies prove the capacity of the vegetal polyphenols to diminish the lipid peroxidation and to reduce the LDL oxidation [10].…”

Section: Resultsmentioning

confidence: 99%

Negative Pressure Therapy in Abdominal Compartment Syndrome

Ciuntu¹,

Vasiluta²,

Anton³

et al. 2017

The abdominal vacuum-assisted closure (VAC) system has been introduced, providing a new possibility to treat an open abdomen. Abdominal compartment syndrome has a great relevance in surgical practice and patient care in critical condition due to the effects of increased pressure in the enclosed space of the abdomen can lead to multiple organ failure. A prospective study was conducted on a sample of 15 patients with severe acute pancreatitis (SAP) was retrospectively analyzed, following the incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS),the effectiveness of the therapeutic methods applied in reducing the intra-abdominal pressure (PIA), the evolution of severity scores, lenght of stay in intensive care unit between January 2014 -March 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC ™ -Hartman) in order to apply negative pressure to the open abdomen, while complying with specified settings in accordance with patients' outcome. Surgery for abdominal decompression in PAS with SCA is an emergency and was imposed on 14 of the 15 patients . In the studied group, the first decompression procedure was performed on days 2 to 5 from intake, as PIA increased in evolution despite medical methods. Only 1 patient hospitalized with SAP PIA decreased by medical methods and after haemofiltration. Acute severe pancreatitis remains a serious pathology in spite of a maximum medical and surgical therapy.Continuous venous haemofiltration has contributed to lowering intraabdominal pressure. Surgery with decompression vacuum systems with negative pressure lead to a significant decrease in PIA.