“…Natural compounds display a plethora of amazing biological properties (Carullo et al., 2022; Pozzetti et al., 2022; Spizzirri et al., 2019). Among them, phenolic, hydroxycinnamic, and benzoic acids (general structure 1 , Figure 1) have been strongly investigated, and their role in both disease prevention and therapy has been extensively demonstrated (Carullo, Ahmed, et al., 2020; Carullo et al., 2021; Carullo, Governa, et al., 2019; Carullo, Perri, et al., 2019; Heleno et al., 2015; Mazzotta et al., 2021; Spizzirri et al., 2019). Phenolic and cinnamic acid derivatives are more efficient antioxidant agents than their benzoic analogs due to the resonance stabilization of the double bond, while relative to aromatic substitution, the antioxidant efficiency inside the class (benzoic or cinnamic) is p ‐hydroxydimethoxy > dihydroxy > p ‐hydroxymethoxy > p ‐hydroxy.…”