Quercetin Hybrids—Synthesis, Spectral Characterization and Radical Scavenging Potential

Kirkova, Desislava; Stremski, Yordan; Statkova-Abeghe, Stela; Docheva, Margarita

doi:10.3390/m1329

Cited by 8 publications

(5 citation statements)

References 30 publications

(29 reference statements)

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“…Consequently, the parent β-CD skeleton structure is maintained in β-CD-K MOFs, as evidenced by the comparison of the FT-IR spectra of β-CD and β-CD-K MOFs (Figure 4). The FT-IR spectrum of QRC agreed with the literature [40,41]. The IR signal appears to be overlapped with β-CD for MOFs lacking QRC.…”

Section: Ft-ir Spectral Analysissupporting

confidence: 86%

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Supramolecular β-Cyclodextrin-Quercetin Based Metal–Organic Frameworks as an Efficient Antibiofilm and Antifungal Agent

et al. 2023

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The loading of drugs or medicinally active compounds has recently been performed using metal–organic frameworks (MOFs), which are thought to be a new type of porous material in which organic ligands and metal ions can self-assemble to form a network structure. The quercetin (QRC) loading and biofilm application on a cyclodextrin-based metal–organic framework via a solvent diffusion approach is successfully accomplished in the current study. The antibacterial plant flavonoid QRC is loaded onto β-CD-K MOFs to create the composite containing inclusion complexes (ICs) and denoted as QRC:β-CD-K MOFs. The shifting in the chemical shift values of QRC in the MOFs may be the reason for the interaction of QRC with the β-CD-K MOFs. The binding energies and relative contents of MOFs are considerably changed after the formation of QRC:β-CD-K MOFs, suggesting that the interactions took place during the loading of QRC. Confocal laser scanning microscopy (CLSM) showed a reduction in the formation of biofilm. The results of the cell aggregation and hyphal growth are consistent with the antibiofilm activity that is found in the treatment group. Therefore, QRC:β-CD-K MOFs had no effect on the growth of planktonic cells while inhibiting the development of hyphae and biofilm in C. albicans DAY185. This study creates new opportunities for supramolecular β-CD-based MOF development for use in biological research and pharmaceutical production.

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Section: Ft-ir Spectral Analysissupporting

confidence: 86%

“…The two neighboring protons in the phenyl group yield a doublet at 7.54 and a doublet at 7.67 ppm. At 9.37 and 12.48 ppm [41], the hydroxy protons appear as the wide signal. Three doublets for four protons are found in the MOFs at 7.51, 7.22, and 6.68 ppm, as well as a broad singlet at 6.19 ppm.…”

Section: Nmr Spectral Analysismentioning

confidence: 98%

Supramolecular β-Cyclodextrin-Quercetin Based Metal–Organic Frameworks as an Efficient Antibiofilm and Antifungal Agent

et al. 2023

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“…The studied molecules were recently synthesized by Desislava Kirkova et al The published work includes the synthesizing procedure as well as an evaluation of radical scavenging activity and spectroscopic characterization data in the supplementary attachments [11]. The five compounds produced by this effort were symbolized as 6a, 6b, 7a, 8a, 8b, and their molecular structures are represented in Figures 1-3.…”

Section: Materials and Methods: Experimental Detailsmentioning

confidence: 99%

Molecular docking analysis of novel quercetin derivatives for combating SARS-CoV-2

Marashdeh¹

2023

Bioinformation

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Quercetin belongs to the flavonoid family, which is one of the most frequent types of plant phenolics. This flavonoid compound is a natural substance having a number of pharmacological effects, including anticancer and antioxidant capabilities, as well as being a strong inhibitor of various toxicologically important enzymes. We discuss the potential of newly recently synthesized quercetin-based derivatives to inhibit SARS-CoV-2 protein. ADMET analysis indicated that all of the studied compounds had low toxicities and good absorption and solubility properties. The molecular docking results revealed that the propensity for binding to SARS-CoV-2 main protease is extraordinary. The results are remarkable not only for the binding energy values, which outperform several compounds in prior studies, but also for the number of hydrogen bonds formed. Compound 7a was capable of forming 10 strong hydrogen bonds as well as interact to the protein receptor with a binding energy of -7.79 kcal/mol. Therefore, these compounds should be highlighted in further experimental studies in the context of treating SARS-CoV-2 infection and its effects.

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“…The IC50 value was calculated for the concentration of the test mixture resulting in a 50% reduction in absorbance when compared to the control. Experiments were carried out in triplicates and the percentage inhibition was determined (Kirkova et al., 2022).…”

Section: Methodsmentioning

confidence: 99%

Comparative study of nanocarrier for Eupatorium perfoliatum 3C by low molecular over high molecular chitosan for efficient encapsulation and dye degradation applications

Revathi

Dey

2023

Environmental Quality Mgmt

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This study focuses on encapsulating the drug with enhanced efficiency and characterizing the same environmental applications. Efficient encapsulation and conjugation of this remarkable drug with chitosan have never been attempted before. Loading into a nanocarrier extends the efficiency of the boneset from being general folk medicine to a specialized functional moiety that even works as potential nanomedicine and dye degeneration. Eupatorium perfoliatum 3C loaded in the chitosan nanocarrier was performed using an ionotropic gelation method. Physicochemical properties were analyzed using a pH meter, UV‐Vis spectrophotometer, scanning electron microscopy, and Fourier Transform Infrared (FTIR) analysis high‐performance liquid chromatography (HPLC). A dye degradation assay was done for four commercially available dyes, namely, safranin, methyl red as well as orange, and methylene blue. Irrespective of chitosan's molecular weight, methyl orange is degraded the most by E. perfoliatum 3C formulation by 31.9% at 90 min. In terms of encapsulation efficiency, lower molecular chitosan shows 96% encapsulation of the drug within its surface. Thus, manifesting itself as a potential nanocarrier for therapeutic applications in the future.

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Quercetin Hybrids—Synthesis, Spectral Characterization and Radical Scavenging Potential

Cited by 8 publications

References 30 publications

Supramolecular β-Cyclodextrin-Quercetin Based Metal–Organic Frameworks as an Efficient Antibiofilm and Antifungal Agent

Supramolecular β-Cyclodextrin-Quercetin Based Metal–Organic Frameworks as an Efficient Antibiofilm and Antifungal Agent

Molecular docking analysis of novel quercetin derivatives for combating SARS-CoV-2

Comparative study of nanocarrier for Eupatorium perfoliatum 3C by low molecular over high molecular chitosan for efficient encapsulation and dye degradation applications

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