7,8-DHF enhances SHH in the hippocampus and striatum during early abstinence but has minor effects on alcohol intake in IA2BC paradigm and abstinence-related anxiety-like behavior in rats

Peregud, D. I.; Kvichansky, A. A.; Shirobokova, N. I.; Stepanichev, M. Yu.; Gulyaeva, N. V.

doi:10.1016/j.neulet.2022.136671

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Both clinical and preclinical studies identify shared targets like mGluR5 for potential AUD treatments, underscoring the model’s validity [ 49 , 50 ]. Furthermore, the model exhibits construct validity, as voluntary drinking mice and AUD patients both show neurochemical irregularities, such as reduced hippocampal and nucleus accumbens volumes [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice

Fu,

Li,

Mai

et al. 2024

IJMS

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Alcohol use disorders (AUDs) frequently co-occur with negative mood disorders, such as anxiety and depression, exacerbating relapse through dopaminergic dysfunction. Stress-related neuropeptides play a crucial role in AUD pathophysiology by modulating dopamine (DA) function. The rostromedial tegmental nucleus (RMTg), which inhibits midbrain dopamine neurons and signals aversion, has been shown to increase ethanol consumption and negative emotional states during abstinence. Despite some stress-related neuropeptides acting through the RMTg to affect addiction behaviors, their specific roles in alcohol-induced contexts remain underexplored. This study utilized an intermittent voluntary drinking model in mice to induce negative effect behavior 24 h into ethanol (EtOH) abstinence (post-EtOH). It examined changes in pro-stress (Pnoc, Oxt, Npy) and anti-stress (Crf, Pomc, Avp, Orx, Pdyn) neuropeptide-coding genes and analyzed their correlations with aversive behaviors. We observed that adult male C57BL/6J mice displayed evident anxiety, anhedonia, and depression-like symptoms at 24 h post-EtOH. The laser-capture microdissection technique, coupled with or without retrograde tracing, was used to harvest total ventral tegmental area (VTA)-projecting neurons or the intact RMTg area. The findings revealed that post-EtOH consistently reduced Pnoc and Orx levels while elevating Crf levels in these neuronal populations. Notably, RMTg Pnoc and Npy levels counteracted ethanol consumption and depression severity, while Crf levels were indicative of the mice’s anxiety levels. Together, these results underscore the potential role of stress-related neuropeptides in the RMTg in regulating the negative emotions related to AUDs, offering novel insights for future research.

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Section: Discussionmentioning

confidence: 99%

Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice

Fu,

Li,

Mai

et al. 2024

IJMS

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Role of BDNF in Neuroplasticity Associated with Alcohol Dependence

Peregud

Baronets

et al. 2023

Biochemistry Moscow

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Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) is believed to be critically involved in this process. Here we aimed to review actual experimental and clinical data related to BDNF participation in neuroplasticity in the context of alcohol dependence. As has been shown in experiments with rodents, alcohol consumption is accompanied by the brain region-specific changes of BDNF expression and by structural and behavioral impairments. BDNF reverses aberrant neuroplasticity observed during alcohol intoxication. According to the clinical data parameters associated with BDNF demonstrate close correlation with neuroplastic changes accompanying alcohol dependence. In particular, the rs6265 polymorphism within the BDNF gene is associated with macrostructural changes in the brain, while peripheral BDNF concentration may be associated with anxiety, depression, and cognitive impairment. Thus, BDNF is involved in the mechanisms of alcohol-induced changes of neuroplasticity, and polymorphisms within the BDNF gene and peripheral BDNF concentration may serve as biomarkers, diagnostic or prognostic factors in treatment of alcohol abuse.

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Role of BDNF in neuroplasticity associated with alcohol dependence

Peregud,

Baronets,

Terebilina

et al. 2023

Biohimiâ

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Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) may mechanistically participate in this process. Here we aimed to review actual experimental and clinical data related to BDNF involvement in neuroplasticity in the context of alcohol dependence. As shown in experiments on the rodents alcohol consumption is accompanied brain region-specific changes of BDNF expression and by structural and behavioral impairments. BDNF reverses aberrant neuroplasticity during alcohol intoxication. According to clinical data indices characterized BDNF demonstrate close relationship with consequences of alcohol dependence. Polymorphism rs6265 within BDNF gene interacts with macrostructural changes in the brain, while peripheral BDNF concentration may reflect anxiety, depression and cognitive decline. Thus, BDNF is involved in mechanisms of alcohol-related aberrant neuroplasticity, while polymorphisms within BDNF gene and peripheral BDNF concentration may be biomarkers, diagnostic or prognostic factors in clinics of alcoholism.

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7,8-DHF enhances SHH in the hippocampus and striatum during early abstinence but has minor effects on alcohol intake in IA2BC paradigm and abstinence-related anxiety-like behavior in rats

Cited by 3 publications

References 38 publications

Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice

Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice

Role of BDNF in Neuroplasticity Associated with Alcohol Dependence

Role of BDNF in neuroplasticity associated with alcohol dependence

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