[6S]-5-Methyltetrahydrofolate enhances folate status in rats fed growing-up milk

Pérez-Conesa, Darío; Haro-Vicente, Juan Francisco; Braquehais, Fernando Romero; Ros, Gaspar

doi:10.1007/s00394-009-0022-1

Cited by 5 publications

(18 citation statements)

References 25 publications

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“…A total of 23 studies out of the original 5226 articles identified fit the full inclusion criteria and were appraised in this review. All studies provided quantitative data with 4 trials [19][20][21][22] using animal models and 19 studies [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] conducting human trials.…”

Section: Resultsmentioning

confidence: 99%

“…Three trials 23,27,35 tested varying different dosages of folate to see the effect on outcome measures. Twelve studies 19,21,22,26,28,29,[31][32][33][34][35][36] compared two or more different forms of folate against each other. One study tested a soft gel capsule versus a tablet 40 and another looked at a powdered formula verses a tablet.…”

Section: Resultsmentioning

confidence: 99%

“…There was also great variation in the forms of folate supplements used. The most frequently tested supplement was folic acid with 15 trials [19][20][21][22][25][26][27]29,30,[33][34][35][38][39][40] using this form. The second most common was (6S)-5methyltetrahydrofolate with eight trials 21,22,26,29,[33][34][35]37 assessing its efficacy.…”

Section: Resultsmentioning

confidence: 99%

“…The dosages used in the human trials varied greatly from only 25 mg up to 200 mg. Of the 12 studies, 19,21,22,26,28,29,[31][32][33][34][35][36] which compared 2 or more different forms of folate, 9 studies 19,26,28,29,[31][32][33][34]36 showed no significant differences between the groups and three studies 21,22,35 showed 5-methylenetetrahydrofolate (5-MTHF) to be the most bioavailable.…”

Section: Resultsmentioning

confidence: 99%

“…This is the first review to explore the bioavailability of different oral forms of folate supplementation in a healthy population. The review highlighted that only 12 studies 19,21,22,26,28,29,[31][32][33][34][35][36] have compared two or more different forms of folate supplementation. The literature from this review did not find a substantial difference between the bioavailability of one or more forms.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review

Bayes

Agrawal

Schloss

2019

The Journal of Alternative and Complementary Medicine

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This review has found a number of methodological limitations and conflicting results. Only three out of the 23 studies assessed found a statistically significant difference between different supplemental forms of folate. Quality absorption studies assessing the bioavailability of oral folate supplements are crucial if clinicians are to make effective evidence-based recommendations. More research is required for greater clarification regarding the bioavailability of these supplements.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review

Bayes

Agrawal

Schloss

2019

The Journal of Alternative and Complementary Medicine

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Natural Folates from Biofortified Tomato and Synthetic 5-methyl-tetrahydrofolate Display Equivalent Bioavailability in a Murine Model

Castorena‐Torres

Ramos-Parra

Hernández-Méndez

et al. 2014

Plant Foods Hum Nutr

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Folate deficiency is a global health problem related to neural tube defects, cardiovascular disease, dementia, and cancer. Considering that folic acid (FA) supply through industrialized foods is the most successful intervention, limitations exist for its complete implementation worldwide. Biofortification of plant foods, on the other hand, could be implemented in poor areas as a complementary alternative. A biofortified tomato fruit that accumulates high levels of folates was previously developed. In this study, we evaluated short-term folate bioavailability in rats infused with this folate-biofortified fruit. Fruit from tomato segregants hyperaccumulated folates during an extended ripening period, ultimately containing 3.7-fold the recommended dietary allowance in a 100-g portion. Folate-depleted Wistar rats separated in three groups received a single dose of 1 nmol of folate/g body weight in the form of lyophilized biofortified tomato fruit, FA, or synthetic 5-CH3-THF. Folate bioavailability from the biofortified tomato was comparable to that of synthetic 5-CH3-THF, with areas under the curve (AUC(0-∞)) of 2,080 ± 420 and 2,700 ± 220 pmol · h/mL, respectively (P = 0.12). Whereas, FA was less bioavailable with an AUC(0-∞) of 750 ± 10 pmol · h/mL. Fruit-supplemented animals reached maximum levels of circulating folate in plasma at 2 h after administration with a subsequent steady decline, while animals treated with FA and synthetic 5-CH3-THF reached maximum levels at 1 h. Pharmacokinetic parameters revealed that biofortified tomato had slower intestinal absorption than synthetic folate forms. This is the first study that demonstrates the bioavailability of folates from a biofortified plant food, showing its potential to improve folate deficiency.

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Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form

et al. 2013

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[6S]-5-Methyltetrahydrofolate enhances folate status in rats fed growing-up milk

Abstract: We conclude that the natural diastereomer [6S]-5-CH(3)-H(4)folate may adequately serve as an alternative to folic acid for the folate fortification of infant foods.

Cited by 5 publications

References 25 publications

The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review

The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review

Natural Folates from Biofortified Tomato and Synthetic 5-methyl-tetrahydrofolate Display Equivalent Bioavailability in a Murine Model

Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form

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