691 Immunocompetence in Obesity

Chandra, Ranjit Kumar; Woodford, G.; Au, B.; Kutty, Karthiyanee

doi:10.1203/00006450-197804001-00696

Cited by 5 publications

(2 citation statements)

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“…It appeared as if their resistance to infection was depressed; however, until recently there have been no measures of assessment of resistance. Studies of malnourished children [16,17] and burn patients [18][19][20] have established the relationship between acquired defects in host defense and an increased incidence of infection.…”

Section: Surgical Services Librarymentioning

confidence: 99%

Predicting surgical infection before the operation

et al. 1980

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To date, simple skin testing using recall antigens has proven to be the most accurate method of assessing preoperative risk for serious infectious complications. When used in conjunction with measures to control the microorganisms and the environment, evaluation of host defense mechanisms with skin testing can aid in reducing postoperative infectious morbidity and mortality.There are 3 possible therapeutic approaches to anergie patients. Surgery and specific nonsurgical treatments (restoration of blood volume, red cell mass, antibiotics), total parenteral nutrition, and immunorestoration. The challenge for the future is to develop the criteria that will indicate the most important defects which account for the anergic state in individual patients.

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Section: Surgical Services Librarymentioning

confidence: 99%

Predicting surgical infection before the operation

et al. 1980

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“…A proportion of obese ado lescents and adults show impaired neutro phil function [4][5][6]15] and reduced cell-me diated immunity [5]. These immunologic changes did not correlate with the severity of obesity or the levels of plasma lipids.…”

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confidence: 99%

Spleen Hemolytic Plaque-Forming Cell Response and Generation of Cytotoxic Cells in Genetically Obese (C57B1/6J <i>ob</i>/<i>ob</i>) Mice

Chandra¹,

Au²

1980

Int Arch Allergy Immunol

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Cell-mediated immune responses were evaluated in genetically obese (C57B1/6J ob/ob) mice and lean controls. The thymus and spleen weighed less and contained fewer mononuclear cells in obese animals compared with controls. The total number of direct and indirect plaque-forming cells in the spleen of obese mice immunized intraperitoneally with sheep red blood cells was reduced, however, when the results were expressed as plaques/10⁶ mononuclear cells, the proportion of antibody-producing cells was higher in the obese. Ob/ob mice immunized in vivo with allogeneic EL-4 lymphoma cells showed markedly diminished capacity to generate cytotoxic cells, whereas such response after in vitro immunization was comparable in the two groups of animals. These observations suggest that altered cell-mediated immune response in obese animals is the result of a deleterious microenvironment.

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Effects of Specific Nutrients on the Immune Response: Selected Clinical Applications

Corman

1985

Medical Clinics of North America

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691 Immunocompetence in Obesity

Abstract: Obese individuals are susceptible t o respiratory and cutaneous infections and post-operative wound sepsis. I n a group o f 2 1 children and adolescents diagnosed t o b e obese on the basis o f weight-forheight and skin-fold thickness, a comprehensive

Cited by 5 publications

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Predicting surgical infection before the operation

Predicting surgical infection before the operation

Spleen Hemolytic Plaque-Forming Cell Response and Generation of Cytotoxic Cells in Genetically Obese (C57B1/6J <i>ob</i>/<i>ob</i>) Mice

Effects of Specific Nutrients on the Immune Response: Selected Clinical Applications

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