Effects of Specific Nutrients on the Immune Response: Selected Clinical Applications

Corman, Lourdes C.

doi:10.1016/s0025-7125(16)31018-5

Cited by 32 publications

(12 citation statements)

References 134 publications

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“…PW mitogen activates primarily the B (but also some T) lymphocytes. Vitamin B-6 has been shown to be important in the immune response against a variety of antigens and insufficient dietary intake may lead to suppression of both humoral and cell-mediated responses (1,2, [23][24][25]. It is also well-documented that the status of T lymphocytes is critical in immunoregulation and normal maintenance of these responses.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of cancer patient leukocyte responses in the presence of physiologic and pharmacologic pyridoxine and pyridoxal levels

Gridley

Stickney

Shultz

1989

Clinical Laboratory Analysis

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Peripheral blood samples from six cancer patients (five colon cancer, one lung cancer) and six healthy volunteers were tested in vitro for oxygen radical production by phagocytic cells and in assays of mitogen-induced lymphoblastogenesis at physiologic and pharmacologic concentrations of pyridoxine (PN, 1.8-96 nmol/ml) or pyridoxal (PL, 0.08-90 nmol/ml). Plasma levels of pyridoxal-5'-phosphate (PLP), 4-pyridoxic acid (4PA), pyridoxamine phosphate (PMP), and PL were also determined. Phagocytic cells from three patients showed significantly increased capacity for oxygen radical production when incubated in PL-, but not PN-supplemented media. Oxygen burst capacity of cells from healthy subjects was significantly enhanced by PN-, but not PL-enriched media. Lymphocyte responsiveness to phytohemagglutinin or pokeweed mitogen (PWM) stimulation showed a modest increase in cell activation in three patients as the concentration of PN was increased; with concanavalin A, two showed enhanced responsiveness. On the other hand, PL-supplementation resulted in greater cell proliferation only with PWM. The cancer patients had significantly lower plasma PLP, 4PA, and PMP levels when compared with the healthy volunteers. These data indicate that in the cancer patients and in a majority of the healthy volunteers, vitamin B-6 status was marginal or deficient and suggest that increasing PN or PL in vivo levels may augment functions related to cell-mediated immunity.

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Section: Resultsmentioning

confidence: 99%

Evaluation of cancer patient leukocyte responses in the presence of physiologic and pharmacologic pyridoxine and pyridoxal levels

Gridley

Stickney

Shultz

1989

Clinical Laboratory Analysis

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“…Theoretically, providing antioxidants in sufficient amounts during exercise-induced oxidative stress may reduce immune dysregulation (91). Furthermore, several reviews (11,15) have emphasized the importance of dietary components, such as antioxidants, on multiple aspects of the immune response and immune system, including the several antioxidants assessed in the current study.…”

Section: Discussionmentioning

confidence: 93%

The Effects of a Nutrient-Enriched Bar on Host Defense Mechanisms and Immunogenicity of Hepatitis a Vaccine During US Army Ranger Training

Wood¹,

Kennedy²,

Shippee³

et al. 2000

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“…The observation that weight loss and/or body composition changes in HIV-infected persons frequently precede development of opportunistic infections and malignancies has led to speculation that malnutrition contributes to progression of this disorder (Chlebowski, 1985). Such speculation is not without foundation, as the impact of specific nutrients on immune status 1 II 111 IV has been well-documented (Corman, 1985). It is recognized, for example, that deficiencies in caloric intake and protein intake have profound effects on the immune system, particularly those processes requiring T-lymphocyte participation (Corman, 1985).…”

mentioning

confidence: 99%

Nutritional Alterations in Persons with HIV Infection

Keithley

Zeller

Szeluga

et al. 1992

Image: the Journal of Nursing Scholarship

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Potential relationships among nutritional status, immune function and quality of life were examined in a convenience sample of 40 outpatient homosexual and bisexual males stratified into five categories, using modified Walter Reed Staging Criteria. Nutritional status was assessed by measuring height, weight, triceps skinfold thickness, arm circumference, nutrient intake and serum albumin. Immune status was evaluated by determining T-helper cell numbers and percentages. The Quality of Life test was used to obtain information about life quality. Nutritional assessment failed to show significant differences among groups with the exception that serum albumin levels were reduced in persons with AIDS. The significance of change in serum albumin in regard to nutritional status is unclear, since serum albumin is affected by a number of non-nutritional factors, such as hydration status and liver function. The study also revealed a significant decline in T-helper percentages, but not absolute T-helper cell numbers as a function of disease stage. There were no statistically significant differences between the quality of life scores with respect to each grouping. These data suggest that asymptomatic patients as well as those with ARC or stable AIDS are able to maintain body weight and composition.

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Effects of Specific Nutrients on the Immune Response: Selected Clinical Applications

Cited by 32 publications

References 134 publications

Evaluation of cancer patient leukocyte responses in the presence of physiologic and pharmacologic pyridoxine and pyridoxal levels

Evaluation of cancer patient leukocyte responses in the presence of physiologic and pharmacologic pyridoxine and pyridoxal levels

The Effects of a Nutrient-Enriched Bar on Host Defense Mechanisms and Immunogenicity of Hepatitis a Vaccine During US Army Ranger Training

Nutritional Alterations in Persons with HIV Infection

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