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Abstract

Sepsis is a type of systemic inflammatory disease caused by polymicrobial infection. To investigate the potential reno-protective benefits of cilostazol during sepsis-induced renal injury, forty male albino Swiss mice, 25 to 30 grams in weight and 8 to 12 weeks old, were employed in the present investigation. Both food and water were freely available to these animals. Mice were separated into the following four groups after two weeks of adaption. (n = 10): (1) Healthy group: apparently normal mice. (2) induced group: mice underwent cecal ligation and puncture operation. (3) DMSO group: mice received DMSO as a vehicle (4) cilostazol group: Cilostazol was administered intraperitoneally to mice for five days in a row at a dose of 5 mg/kg/day. Compared to the CLP group, the cilostazol group showed a significantly (p<0.05) lower amount of NGAL in the kidneys. Additionally, compared to the CLP group, the cilostazol group showed a substantial (p0.05) decline in the levels of serum of inflammatory cytokines (IL-1β, TNF-α, & Interleukin-6). Additionally, compared to the CLP group, the cilostazol group had a significantly (p<0.05) increased renal SOD activity and decreased MDA level. Histologically, all animals in the CLP group displayed a substantial level of kidney tissue damage (p<0.05), whereas the cilostazol group displayed a significantly diminished level of kidney tissue injury. Their capacity to lower serum levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6) has an anti-inflammatory impact. Additionally, they have an antioxidant impact by raising renal SOD activity and lowering renal MDA levels.

Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

“…People suffering from psoriasis are more likely to have complications that are not limited to skin conditions. These encompass type 2 diabetes, obesity, coronary artery diseases, autoimmune diseases, and psychiatric issues. − There is more evidence that psoriasis may arise simultaneously or consecutively with additional immune-mediated skin eruptions, most notably eczematous dermatitis. − Research has also revealed links between psoriasis and an array of immune-associated conditions, among them ulcerated intestinal colitis. − In addition, kidney impairment is known as one of the consequences of psoriasis. − Moreover, arrays of drugs have been significantly implicated in the initiation and aggravation of psoriasis, namely, chloroquine, interferons, imiquimod, tetracyclines, and β-blocking agents …”