“…70,75,126,127 In tandem with past investigations, an 8day administration of imiquimod to mouse dorsal skinfolds gave rise to psoriasiform plaques characterized by redness, desquamation, and acanthosis, along with upregulated expression of pro-inflammatory, angiogenic, and oxidative parameters. 31,32,38,72 It was documented that the skin lesions in the imiquimodapplied murine model, involving redness, acanthosis/thickening, scaling/flaking, cutaneous histology modifications (Munro's abscesses, hyperkeratosis, parakeratosis), and sproutingangiogenesis, alongside an inflammatory penetration made up of T lymphocytes, mast cells, neutrophils, and dendritic cell populations, were remarkably similar to those observed in human psoriasis vulgaris. 71,76 Previous studies have indicated that erythema signifies the degree of cutaneous vasodilation that is compounded by dendritic cells, mast cells, and keratin cells, all of which are believed to generate elements that cause inflammation, involving histamine and nitric oxide.…”