68Ga-PSMA-11 PET/CT in Isolated Bilateral Adrenal Metastases From Prostate Adenocarcinoma

Zhao, Qian; Yang, Bo; Dong, Aisheng; Zuo, Chuantao

doi:10.1097/rlu.0000000000003759

Cited by 6 publications

(7 citation statements)

References 12 publications

(20 reference statements)

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“…2 However, isolated adrenal gland metastases of PCa are extremely rare, and few case reports have been published in literature. [3][4][5][6] In the present case, 68 Ga-PSMA PET/CT demonstrated isolated adrenal gland metastases with intense PSMA uptake, which helped to determine the oligometastatic disease accurately and justified metastasis-directed treatments. However, the high incidence of adrenal insufficiency after surgery or radiotherapy complicated the treatment of choice in this patient.…”

mentioning

confidence: 50%

“…Although bone and lung are the most common sites of hematogeneous metastases in PCa, the autopsy case series reported that 12.8% of patients had adrenal gland metastasis, primarily associated with other metastases 2 . However, isolated adrenal gland metastases of PCa are extremely rare, and few case reports have been published in literature 3–6 . In the present case, 68 Ga-PSMA PET/CT demonstrated isolated adrenal gland metastases with intense PSMA uptake, which helped to determine the oligometastatic disease accurately and justified metastasis-directed treatments.…”

mentioning

confidence: 51%

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Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Topal,

Has Simsek,

Vatansever

et al. 2023

Clin Nucl Med

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We present isolated bilateral adrenal metastases successfully treated with 177Lu-PSMA in a 66-year-old man diagnosed with castration-resistant prostate cancer. The patient had progression under chemotherapy as depicted by 68Ga-PSMA PET/CT showing intense bilateral PSMA uptake in the adrenal masses, and metastasis-directed therapies were considered as the first option for improving survival because the patient was oligometastatic. However, surgery and radiotherapy were not justifiable options due to the high risk of definitive adrenal insufficiency; therefore, the patient received 4 cycles of 177Lu-PSMA treatment. 68Ga-PSMA PET/CT showed near-complete response in bilateral adrenal metastases, and no sign of adrenal insufficiency was observed during follow-up.

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confidence: 50%

mentioning

confidence: 51%

Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Topal,

Has Simsek,

Vatansever

et al. 2023

Clin Nucl Med

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“…Nevertheless, several PET and SPECT studies with radiolabeled PSMAPET radiotracers were also performed in patients with thyroid cancer [83], hepatocellular carcinoma [84], prostate adenocarcinoma [85], glioblastoma [86], myeloma [87], sinonasal glomangioperi-cytoma [88], Sjögren syndrome [89], and bladder cancer [90], which shows PSMA-targeted radiotracers are now playing an increasing role in the diagnostic imaging of patients.…”

Section: Prostate-specific Membrane Antigen (Psma)mentioning

confidence: 99%

Role of Peptides in Diagnostics

Pandey

Malviya

Dvoráková

2021

IJMS

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The specificity of a diagnostic assay depends upon the purity of the biomolecules used as a probe. To get specific and accurate information of a disease, the use of synthetic peptides in diagnostics have increased in the last few decades, because of their high purity profile and ability to get modified chemically. The discovered peptide probes are used either in imaging diagnostics or in non-imaging diagnostics. In non-imaging diagnostics, techniques such as Enzyme-Linked Immunosorbent Assay (ELISA), lateral flow devices (i.e., point-of-care testing), or microarray or LC-MS/MS are used for direct analysis of biofluids. Among all, peptide-based ELISA is considered to be the most preferred technology platform. Similarly, peptides can also be used as probes for imaging techniques, such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET). The role of radiolabeled peptides, such as somatostatin receptors, interleukin 2 receptor, prostate specific membrane antigen, αβ3 integrin receptor, gastrin-releasing peptide, chemokine receptor 4, and urokinase-type plasminogen receptor, are well established tools for targeted molecular imaging ortumor receptor imaging. Low molecular weight peptides allow a rapid clearance from the blood and result in favorable target-to-non-target ratios. It also displays a good tissue penetration and non-immunogenicity. The only drawback of using peptides is their potential low metabolic stability. In this review article, we have discussed and evaluated the role of peptides in imaging and non-imaging diagnostics. The most popular non-imaging and imaging diagnostic platforms are discussed, categorized, and ranked, as per their scientific contribution on PUBMED. Moreover, the applicability of peptide-based diagnostics in deadly diseases, mainly COVID-19 and cancer, is also discussed in detail.

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“…Usually, prostate cancer tends to metastasize to bones and pelvic lymph nodes 1 . There have been reports of uncommon places where prostate cancer metastases have been observed with the PSMA PET/CT imaging 2–4 . On the other hand, there is a scarcity of data regarding prostate cancer metastases detected in the mediastinum.…”

mentioning

confidence: 99%

“…1 There have been reports of uncommon places where prostate cancer metastases have been observed with the PSMA PET/CT imaging. [2][3][4] On the other hand, there is a scarcity of data regarding prostate cancer metastases detected in the mediastinum. Only a few case reports have reported metastases to the mediastinal area.…”

mentioning

confidence: 99%

The 99mTc-MIP-1404 PSMA Uptake in the Isolated Paratracheal Lymph Node From the Prostate Adenocarcinoma

Jonusas¹,

Tiškevičius

Janulionis³

2022

Clin Nucl Med

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The oncologist consulted a 56-year-old man after receiving prostate-specific antigen screening results. Prostate-specific antigen level during the screen time was 33 ng/mL. As a result, poorly differentiated prostate adenocarcinoma with a Gleason score of 9 (5 + 4) was diagnosed. SPECT/CT scan with 99m Tc-MIP-1404 PSMA tracer was performed. The 99m Tc-PSMA–positive lesions were detected in the prostate, external iliac, obturator lymph nodes of the pelvis, para-aortic, and the right lower paratracheal space. The patient was prescribed androgen deprivation therapy and early chemotherapy with docetaxel (6 fractions), after which radiation therapy to prostate and seminal vesicles was planned.

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68Ga-PSMA-11 PET/CT in Isolated Bilateral Adrenal Metastases From Prostate Adenocarcinoma

Cited by 6 publications

References 12 publications

Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Role of Peptides in Diagnostics

The 99mTc-MIP-1404 PSMA Uptake in the Isolated Paratracheal Lymph Node From the Prostate Adenocarcinoma

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