Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Topal, Edanur; Has Simsek, Duygu; Vatansever, Sezai; Sanli, Yasemin; Kuyumcu, Serkan

doi:10.1097/rlu.0000000000004964

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…4 Adrenal metastases have been only a few cases reported. [5][6][7][8] False-positive adrenal PSMA uptake has also been reported. 9 Oligometastatic cases have undergone adrenalectomy.…”

Section: Figurementioning

confidence: 99%

Bilateral Adrenal Metastasis of Prostatic Adenocarcinoma on 68Ga-PSMA PET/CT Imaging

Beyhan,

Turan Bektaş,

Baloğlu

et al. 2024

Clin Nucl Med

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An 84-year-old man with prostate adenocarcinoma underwent 68Ga-PSMA PET/CT due to PSA recurrence. Foci of 68Ga-PSMA uptake were observed in bilateral adrenal glands. Adrenal MRI showed metastasis only in the left adrenal gland. Metastatic 68Ga-PSMA uptake was also observed in the mediastinum and bone. Enzalutamide treatment was started. Follow-up 68Ga-PSMA PET/CT scan showed regression in both adrenal gland metastases and other metastases.

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“…4 Adrenal metastases have been only a few cases reported. [5][6][7][8] False-positive adrenal PSMA uptake has also been reported. 9 Oligometastatic cases have undergone adrenalectomy.…”

Section: Figurementioning

confidence: 99%

Bilateral Adrenal Metastasis of Prostatic Adenocarcinoma on 68Ga-PSMA PET/CT Imaging

Beyhan,

Turan Bektaş,

Baloğlu

et al. 2024

Clin Nucl Med

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177Lu-PSMA radioligand therapy for isolated bilateral adrenal metastases from prostate cancer

Perrone,

Ghai,

Eismant

et al. 2024

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Case report: Synchronous prostate cancer and renal cell carcinoma with prostate cancer-origin metastases to adrenal and renal hilar lymph nodes

Zhang,

Chen,

et al. 2024

Front. Oncol.

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BackgroundSynchronous occurrence of prostate cancer (PCa) and renal cell carcinoma (RCC) is uncommon. RCC has a higher tendency to metastasize to the adrenal glands, renal hilar, and retroperitoneal lymph nodes compared to PCa. To date, there are no documented cases existing where metastatic tumors in these regions, observed in patients concurrently with PCa and RCC, have originated from the PCa rather than the RCC.Case presentationIn this case report, we described a 67-year-old male presented with dysuria for two months and left lower extremity edema for three days. Percutaneous biopsies revealed synchronous primary RCC and PCa. However, the origin of the metastatic tumors, especially those involving the adrenal glands, renal hilum, and retroperitoneal regions, remained undetermined. Subsequent surgical procedures identified that the metastatic lesions originated from the PCa, while the RCC was localized. Ultimately, the patient with metastatic hormone-sensitive prostate cancer (mHSPC) received combination therapy with rezvilutamide and goserelin, which resulted in a satisfactory treatment response.ConclusionIn patients with concurrent PCa and RCC, metastatic lesions in the adrenal glands, renal hilar, and retroperitoneal lymph nodes may also originate from the PCa. Accurate identification of the primary tumor and proper staging are critical for the appropriate management of patients with multiple primary malignancies with concurrent metastases.

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Isolated Adrenal Metastases of Castration-Resistant Prostate Cancer

Cited by 3 publications

References 10 publications

Bilateral Adrenal Metastasis of Prostatic Adenocarcinoma on 68Ga-PSMA PET/CT Imaging

Bilateral Adrenal Metastasis of Prostatic Adenocarcinoma on 68Ga-PSMA PET/CT Imaging

177Lu-PSMA radioligand therapy for isolated bilateral adrenal metastases from prostate cancer

Case report: Synchronous prostate cancer and renal cell carcinoma with prostate cancer-origin metastases to adrenal and renal hilar lymph nodes

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