68Ga DOTATATE PET/CT Imaging of a Solitary Fibrous Tumor of the Nasopharynx

Abstract

Solitary fibrous tumors (SFTs) are rare group of mesenchymal tumors that occurs predominantly in the pleura. The role of PET/CT imaging in characterizing the SFT is not well reported. Mesenchymal tumors may express somatostatin receptors. We hereby report a rare case of SFT of the nasopharynx showing Ga DOTATATE avidity.

68Ga-PSMA–Avid Intranasal Solitary Fibrous Tumor

“…Lensing et al 10 have shown 18 F-PSMA avidity within a pleural SFT in a patient with diagnosed prostate cancer. Furthermore, the avidity for 68 Ga-DOTATATE has also been demonstrated in SFTs 11,12 . In our reference case of a rare presentation of extrapulmonary SFT, 68 Ga-PSMA has shown better avidity in comparison to the 18 F-FDG imaging.…”

Continued rapid growth in 68Ga applications: update 2013 to June 2014

“…Solitary fibrosis tumour of the nasopharynx and coexistence of pituitary macroadenoma and multiple paragangliomas were detected using [ 68 Ga]Ga‐DOTA‐TATE. The agent was found valuable in evaluation of children with opsoclonus‐myoclonus ataxia syndrome providing rapid diagnosis and staging as well as guiding patient management .…”

False-Positive 68Ga-DOTATATE Uptake in a Uterine Subserosal Fibroid Mimicking Mesenteric Neuroendocrine Tumor

“…Ga-DOTATATE uptake has been frequently reported in various nonendocrine tumors and lesions resulting in interpretative errors. [7][8][9][10] According to Kagna et al, 11 the 68 Ga-DOTA-NOC uptake was not associated with any NET in 72% of cases, and the uterus was the third most common location of tracer accumulation. Furthermore, the benign uptake of DOTATATE tracer by uterine fibroid has been described in few studies, attributing to the aberrant expression of somatostatin receptors or hypermetabolism of the fibroid tissue.…”

“…Although the 68 Ga-DOTATATE PET/CT scans are highly sensitive and specific in detecting NETs, false-positive uptake may lead to diagnostic challenges 3–6 . 68 Ga-DOTATATE uptake has been frequently reported in various nonendocrine tumors and lesions resulting in interpretative errors 7–10 . According to Kagna et al, 11 the 68 Ga-DOTA-NOC uptake was not associated with any NET in 72% of cases, and the uterus was the third most common location of tracer accumulation.…”