Continued rapid growth in ⁶⁸Ga applications: update 2013 to June 2014

Abstract

The worldwide utilization of (68) Ga-radionuclide for the fundamental research and clinical applications is growing exponentially. A broad range of (68) Ga-based imaging agents has been explored during recent years. The development of new clinically useful agents is encouraged by many factors; for example, increasing role of positron emission tomography (PET) in nuclear medicine, discovery of new biomarkers, accessibility of (68) Ga, and establishment of PET radiopharmaceutical regulation and legislation. The focus of this review resides on the reports regarding (68) Ga-related research and applications published during 2013 to June 2014.

Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands

“…The pHpotentiometric titrations were made with standardized 0.2 M NaOH. (1): N,N´-dibenzylethylenediamine (3.00 g; 12.48 mmol) and Na 2 CO 3 (5.12 g; 48.67 mmol) were stirred at room temperature in dry acetonitrile (50 mL) for 30 min. Tert-butylbromoacetate (4.64 g; 23.72 mmol), dissolved in dry acetonitrile (10 mL), was added at room temperature over period of 30 min.…”

“…The Ga 3+ -DATA m and Ga 3+ -DATA 5m equilibrium systems have also been investigated by 1 The 1 H-and 71 Ga-NMR data have also been used to calculate the stability and protonation constants of Ga(DATA m ) and Ga(DATA 5m ) complexes by taking into account the integrals of Figure 2; Ga(DATA 5m ): CH 3 -N-(2.35 ppm), see Figure S1; and 71…”

“…The structural behavior and the dynamic processes of the Ga(DATA m ), Ga(DATA 5m ) --and Ga(AAZTA) --complexes were followed by 1 …”

“…The established diagnostic power of the Positron Emission Tomography (PET) technique in MI and the increasing availability of new biological targeting vectors have led to the design and testing of a large number of radiopharmaceuticals in oncology, cardiology, neurology, and infectious diseases. [1] The introduction of radionuclides like 3 H, 11 C or 18 F to biological targeting vectors needs time consuming synthesis. Taking the half-life of these nuclides into account, this is the main disadvantage for these radioisotopes in means of preparation and examination of their derivatives.…”

“…The kinetic inertness of Ga(DATA m ) and Ga(DATA 5m ) complexes was investigated via the exchange reactions with Cu 2+ and transferrin under near physiological conditions. The solution structures and dynamics of the Ga(DATA m ) and Ga(DATA 5m ) complexes have also been investigated by 1 H-NMR spectroscopy.…”