6554 POSTER Serum sialyl Lewisx and cytokeratin 19 fragment as a predictive factors for recurrence in patients with stage I non-small cell lung cancer

Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

“…3 Cell surface carbohydrate structures as part of glycosylated proteins, peptides, and lipids are characteristic signatures of different cell types [4][5][6][7][8] and are associated with many forms of cancer. 9,10 For example, the sialyl Lewis X (sLe x ) antigen is being assessed in many cancers; serum sLe x and the cytokeratin 19 fragment are said to be predictive factors for recurrence in patients with stage I non-small cell lung cancer; 11 and sLe x plus CA 15.3 levels in serum of breast cancer patients were reported to be more effective than CA 15.3 plus CEA in diagnosing cancer. 12 Furthermore, the combination of sLe x and sLe a expression is known to be correlated with the adhesion of urothelial cancer cells to activated endothelium.…”