Carbohydrate biomarkers for future disease detection and treatment

Cheng, Yunfeng; Li, Minyong; Wang, Shaoru; Peng, Hanjing; Reid, Suazette; Ni, Nanting; Fang, Hao; Xu, Wenfang; Wang, Binghe

doi:10.1007/s11426-010-0021-3

Cited by 31 publications

(12 citation statements)

References 320 publications

(327 reference statements)

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“…The mice inoculated with Gram-negative bacteria, and its LPS showed great elevation in haptoglobin and other acute-phase proteins. The suspicious role of sharp induction for acute-phase proteins in inflammation, neuronal necrosis, and cerebral vascular congestion has been deeply in murine [ 72 ].…”

Section: Acute-phase Proteinsmentioning

confidence: 99%

The crucial roles of inflammatory mediators in inflammation: A review

et al. 2018

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The inflammatory response is a crucial aspect of the tissues’ responses to deleterious inflammogens. This complex response involves leukocytes cells such as macrophages, neutrophils, and lymphocytes, also known as inflammatory cells. In response to the inflammatory process, these cells release specialized substances which include vasoactive amines and peptides, eicosanoids, proinflammatory cytokines, and acute-phase proteins, which mediate the inflammatory process by preventing further tissue damage and ultimately resulting in healing and restoration of tissue function. This review discusses the role of the inflammatory cells as well as their by-products in the mediation of inflammatory process. A brief insight into the role of natural anti-inflammatory agents is also discussed. The significance of this study is to explore further and understand the potential mechanism of inflammatory processes to take full advantage of vast and advanced anti-inflammatory therapies. This review aimed to reemphasize the importance on the knowledge of inflammatory processes with the addition of newest and current issues pertaining to this phenomenon.

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Section: Acute-phase Proteinsmentioning

confidence: 99%

The crucial roles of inflammatory mediators in inflammation: A review

et al. 2018

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“…BPN capsules are stable in the presence of the competing carbohydrates in biological environments, which gives BPN capsules the potential to be exploited in biological applications. For example, intracellular drug delivery systems, extracellular remote‐controlled drug delivery systems, closed‐loop insulin delivery systems, biological targeting systems, and biomimetic protocells could all potentially be engineered from BPN capsules.…”

mentioning

confidence: 99%

Boronate–Phenolic Network Capsules with Dual Response to Acidic pH and cis‐Diols

Guo

Sun

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et al. 2015

Adv Healthcare Materials

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Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials. The BPN capsules are stable in the presence of competing carbohydrates, but dissociate at acidic pH or in the presence of competing cis-diols at physiological pH. This engineered capsule system provides a platform for a wide range of biological and biomedical applications.

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“…To ensure the feasibility of the complete automation, a new type of linker (13) stable under the most common glycosylation and protecting group removal conditions was introduced. The synthesis of pentasaccharide (18) began with the assembly of the chitobiose portion using two glycosylation-deprotection cycles with the glycosyl donor (14). A challenging β-mannosidic linkage was then obtained with a donor (15), equipped with a 2-(hydroxycarbonyl)benzyl leaving group developed by Kim [112].…”

Section: Dedicated Oligosaccharide Synthesizer For the Automation Of mentioning

confidence: 99%

“…Isolation from natural sources offers another viable means to obtain sugars. Only the synthetic approach, however, can provide unnatural glycomimetics, which are often of interest due to their therapeutic [4,14] and/or diagnostic potential [15][16][17]. Manufacturers have shown an interest in producing carbohydrate-based pharmaceuticals; however, even with significant progress, controlled chemical synthesis of complex carbohydrates remains difficult.…”

mentioning

confidence: 99%