643 Radiosensitization of human prostate cancer by natural polyphenol inhibitor of Bcl-2/XL, (−)-gossypol, results in tumor regression

Xu, Limei; Yang, Da; Wang, S.; Tang, Wei; Liu, M.; Chen, J.; Lawrence, Thomas J.; Lippman, ME

doi:10.1016/s1359-6349(04)80651-7

Cited by 3 publications

(2 citation statements)

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“…Therefore, it is widely used in medical and pharmaceutical field. Recently, some bio‐medical research5–11 suggested that gossypol is a promising novel anticancer drug. Gossypol has two enantiomers.…”

Section: Introductionmentioning

confidence: 99%

Increased incidence of symptomatic venous thrombosis in patients with cervical carcinoma treated with concurrent chemotherapy, radiation, and erythropoietin

Wun¹,

Law²,

Harvey³

et al. 2003

Cancer

136

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To investigate the extracted process of gossypol acetic acid (G‐AA) from cottonseed soapstock and explore the improvement of its yield and purity, a novel ultrasound‐assisted extraction and crystallization method was introduced to this process. Under the optimized conditions, preliminary G‐AA with the yield of 1300 mg and the purity of 95.9% could be obtained from 100 g of fresh soapstock by ultrasound‐assisted extraction. In addition, UV, IR, and NMR spectrum further confirmed the detailed chemical structure of G‐AA. Assay of inhibiting human prostate tumor cell line PC‐3 and human breast cancer cell line MDA‐MB‐231 revealed its biological activity, the values of IC50 are 9.096 μmol/L and 14.37 μmol/L respectively. In comparison with the conventional solvent extraction, this novel process increases the content of G‐AA over 90%, reduces the time of crystallization by 75%, and retains the anticancer activity of gossypol. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Section: Introductionmentioning

confidence: 99%

Increased incidence of symptomatic venous thrombosis in patients with cervical carcinoma treated with concurrent chemotherapy, radiation, and erythropoietin

Wun¹,

Law²,

Harvey³

et al. 2003

Cancer

136

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“…However, it should be noted that gossypol use as a medicinal product is limited by low therapeutic breadth of the doses applied, especially systemic ones. Gossypol is known to exert negative effect on erythro-and myelopoiesis, have hepatotoxicity, suppress spermatogenesis, therefore being limited in medicine for long time (16)(17)(18). It caused interest due to identification of new properties of its derivatives.…”

Section: Historymentioning

confidence: 99%

Preclinical and Clinical Evidence of Safety of Antiviral Drug with Immunomodulatory Activity

Borovskaya

2018

Serbian Journal of Experimental and Clinical Research

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Antiviral drug Kagocel is widely used in Russia for prevention and treatment of acute respiratory infection, influenza, and herpes. The drug belongs to the group of interferon inductors. The article contains the review and analytical evaluation of safety of antiviral drug Kagocel. Kagocel is registered in the Russian Federation and some CIS countries and refers to the group of interferon inducers. This is a chemical compound of carboxymethyl cellulose and low-molecular natural polyphenol gossypol common in cotton-plant (Gossypium spp.) which protects the plant from depredators and diseases. Authors pay a special attention to the analysis and generalization of data from preclinical and clinical studies including the control of related substances. Absence of free gossypol impurities guaranteed by highly sensitive and specific quality control methods. Preclinical studies data was analyzed and the results were presented with focus on reproductive safety of Kagocel® in immature and mature animals.. No negative effect on animals’ reproductive function was revealed including spermatogenesis and generative function. No long-term product effect on reproductive system or next generations of animals was recorded both at therapeutic doses and at doses 10 times their exceeding. The safety of the drug demonstrated on data obtained from numerous clinical trials, including those involving children aged 2 years and older. Th is confirms the safety of antiviral drug Kagocel usage in clinical practice, including pediatrics.

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An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock

Jia

Zhan

et al. 2009

AIChE Journal

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in Wiley InterScience (www.interscience.wiley.com).To investigate the extracted process of gossypol acetic acid (G-AA) from cottonseed soapstock and explore the improvement of its yield and purity, a novel ultrasoundassisted extraction and crystallization method was introduced to this process. Under the optimized conditions, preliminary G-AA with the yield of 1300 mg and the purity of 95.9% could be obtained from 100 g of fresh soapstock by ultrasound-assisted extraction. In addition, UV, IR, and NMR spectrum further confirmed the detailed chemical structure of G-AA. Assay of inhibiting human prostate tumor cell line PC-3 and human breast cancer cell line MDA-MB-231 revealed its biological activity, the values of IC 50 are 9.096 lmol/L and 14.37 lmol/L respectively. In comparison with the conventional solvent extraction, this novel process increases the content of G-AA over 90%, reduces the time of crystallization by 75%, and retains the anticancer activity of gossypol.

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643 Radiosensitization of human prostate cancer by natural polyphenol inhibitor of Bcl-2/XL, (−)-gossypol, results in tumor regression

Cited by 3 publications

References 0 publications

Increased incidence of symptomatic venous thrombosis in patients with cervical carcinoma treated with concurrent chemotherapy, radiation, and erythropoietin

Increased incidence of symptomatic venous thrombosis in patients with cervical carcinoma treated with concurrent chemotherapy, radiation, and erythropoietin

Preclinical and Clinical Evidence of Safety of Antiviral Drug with Immunomodulatory Activity

An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock

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