A 47-year-old woman sought medical attention after 1 week of progressive fatigue, scleral icterus, and dark urine. She had no fever, cough, or shortness of breath. She had no history of HIV, cancer, autoimmune disease, recent infection, diarrhea, or new medication/supplements. In addition, she had no history of out-of-state travel. On examination at the time of admission, she had mild scleral icterus, normal spleen size, no evidence of petechiae or purpura, and a normal neurological examination. Laboratory tests revealed a white blood cell count of 4.8 K/µL, hemoglobin level of 11.5 g/dL, and platelet count of 8 K/µL. She was admitted and tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by nasopharyngeal swab via reverse transcription polymerase chain reaction (RT-PCR). Additional laboratory values were as follows: total bilirubin, 1.7 mg/dL; creatinine, 0.87 mg/dL; lactate dehydrogenase (LDH), 708 U/L; reticulocytes, 1.22%; haptoglobin, <9 mg/dL; prothrombin time, 13.1; and partial thromboplastin time (PTT), 26.6. mg/dL; fibrinogen, 389 mg/dL; and C-reactive protein, 0.1 mg/dL. D-dimer was elevated at 3.9 µg/mL. Normal values for test results are given in Table 1. A direct antiglobulin test (DAT) was negative. The results of a urine pregnancy test were negative. She had extensive negative workup for nonimmune