Untitled

Voronina, A. S.

doi:10.1023/a:1021669506664

Cited by 15 publications

(10 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results corroborate our hypothesis on the role of activation of some mRNAs in cell transition from a competence to the determination at an embryogenesis [2].…”

Section: Spatial Patterning Of the Xvent-2 Protein Insupporting

confidence: 91%

“…The expression of many genes in embryo development of eukaryotes is regulated at the translational level by variety of mechanisms [2]. The individual templates differ in specific localization within the embryo, activity time, and mechanisms of masking and translational activation.…”

Section: Most Of the Xvent-2 Mrna Is Not Translatedmentioning

confidence: 99%

“…However there are lots of evidences that mRNA may present in a cell in inactive ribonucleoprotein complexes, called by different names, from informosomes to p-bodies [1]. As a rule the start up of protein synthesis on such messengers is regulated by the modifications of the mRNA-binding proteins and the translation factors [2]. The new-synthesized proteins also undergo some modifications, and that causes their activities.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of the transcription factor Xvent-2 in <i>Xenopus laevis</i> embryogenesis

Pshennikova¹,

Voronina²

2012

AJMB

View full text Add to dashboard Cite

Till now the transcription factor Xvent-2 has been studied in Xenopus embryos only by the mRNA testing. We use immunochemical methods for testing of the Xvent-2 protein and gradient-centrifugation methods for estimation of activity of its mRNA. Our results show that the Xvent-2 protein is present in eggs and early embryos. The Xvent-2 mRNA is absent at any of these developmental stages. The majority of mRNA synthesized on the zygotic genome was stored in informosomes, while only its small part could be revealed in polysomes. The spatial patterning of the Xvent-2 protein at different developmental stages did not entirely agree with that of its mRNA. These data indicate that the Xvent-2 protein functioning in Xenopus embryos is regulated not only at the transcription, but at translation and posttranslation as well. We propose that the activation of translation on the masked Xvent-2 mRNA may lead to blood differentiation and cell migration.

show abstract

“…Our results corroborate our hypothesis on the role of activation of some mRNAs in cell transition from a competence to the determination at an embryogenesis [2].…”

Section: Spatial Patterning Of the Xvent-2 Protein Insupporting

confidence: 91%

Section: Most Of the Xvent-2 Mrna Is Not Translatedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of the transcription factor Xvent-2 in <i>Xenopus laevis</i> embryogenesis

Pshennikova¹,

Voronina²

2012

AJMB

View full text Add to dashboard Cite

show abstract

“…Different cis-regulatory elements and transacting factors were characterized in the reviews. 12,[14][15][16][17][18][19][20] Some data indicate the role of trans-acting ribosomal proteins in directing the translation of specific mRNAs. 18 The miRNAs role in the mRNA masking and demasking was also reported.…”

Section: Regulation Of Mrna Activitymentioning

confidence: 99%

“…Several elements in 3 0 -UTR required for deadenylation were described. 14,38,39 The cis-acting tandemly repeated element (TGE) was found in Caenorhabditis elegans, Xenopus and humans. In embryos, TGE suppresses translation of the mRNAs having poly(A) tails only.…”

Section: Mrna Deadenylationmentioning

confidence: 99%

mRNPs: Structure and role in development

Voronina

Pshennikova

2021

Cell Biochemistry & Function

View full text Add to dashboard Cite

In eukaryotic cells, mRNA molecules are coated with numerous RNA‐binding proteins and so exist in ribonucleoproteins (mRNPs). The proteins associated with the mRNA regulate the fate of mRNA, including its localization, translation and decay. Before activation of translation, the mRNA does not display any template functions—it is masked. The coordinated activity of certain RNA‐binding proteins determines the future fate of each mRNA individually. In embryo development, the temporal and spatial regulation of translation can cause a situation when the mRNA and the encoded protein are localized in different compartments and so the differentiation of the cells can be determined. The fundamentals of regulation of the mRNAs fate and functioning in nerves are similar to those already described for oo‐ and embryogenesis. Disorders in the mRNA masking and demasking result in the emergence of various diseases, in particular cancers and neuro‐degenerative diseases.

show abstract

Molecular Mechanisms of Germ Line Cell Determination in Animals

et al. 2005

View full text Add to dashboard Cite

Untitled

Cited by 15 publications

References 66 publications

Expression of the transcription factor Xvent-2 in <i>Xenopus laevis</i> embryogenesis

Expression of the transcription factor Xvent-2 in <i>Xenopus laevis</i> embryogenesis

mRNPs: Structure and role in development

Molecular Mechanisms of Germ Line Cell Determination in Animals

Contact Info

Product

Resources

About

Untitled

Cited by 15 publications

References 66 publications

Expression of the transcription factor Xvent-2 in &lt;i&gt;Xenopus laevis&lt;/i&gt; embryogenesis

Expression of the transcription factor Xvent-2 in &lt;i&gt;Xenopus laevis&lt;/i&gt; embryogenesis

mRNPs: Structure and role in development

Molecular Mechanisms of Germ Line Cell Determination in Animals

Contact Info

Product

Resources

About

Expression of the transcription factor Xvent-2 in <i>Xenopus laevis</i> embryogenesis

Expression of the transcription factor Xvent-2 in <i>Xenopus laevis</i> embryogenesis