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Rensen, A. J. M. L. Van; Wauben, Marca H. M.; Grosfeld-Stulemeyer, M. C.; Eden, Willem van; Crommelin, Daan J.A.

doi:10.1023/a:1018864005620

Cited by 15 publications

(1 citation statement)

References 27 publications

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“…For example, the major histocompatibility complex (MHC) expression on the extracellular-side of antigen-presenting cells is essential for the molecular recognition of pathogens. [209][210][211] Therefore it is not surprising that decorating the outer membrane of vesicles has been vastly described for targeted drug delivery and release. [212][213][214][215][216][217][218] For example, PEO-b-PCL polymersomes (100 nm) conjugated with mouse-anti-rat monoclonal antibody OX26 (OX26-PO) were used to deliver drugs to the brain as the antibody can bind to a specific receptor which initiates transcytosis through the bloodbrain barrier.…”

Section: Review Articlementioning

confidence: 99%

Liposomes and polymersomes: a comparative review towards cell mimicking

et al. 2018

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Cells are integral to all forms of life due to their compartmentalization by the plasma membrane. However, living organisms are immensely complex. Thus there is a need for simplified and controllable models of life for a deeper understanding of fundamental biological processes and man-made applications. This is where the bottom-up approach of synthetic biology comes from: a stepwise assembly of biomimetic functionalities ultimately into a protocell. A fundamental feature of such an endeavor is the generation and control of model membranes such as liposomes and polymersomes. We compare and contrast liposomes and polymersomes for a better a priori choice and design of vesicles and try to understand the advantages and shortcomings associated with using one or the other in many different aspects (properties, synthesis, self-assembly, applications) and which aspects have been studied and developed with each type and update the current development in the field.

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