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Structural and theoretical studies of 4-chloro-2-methyl-6-oxo-3,6-dideuteropyrimidin-1-ium chloride (d 6)

“…Pyrimidines represent one of the most active classes of compounds, possessing a wide spectrum of biological activities such as significant in vitro activity against unrelated DNA and RNA viruses including polio herpes viruses, and diuretic, antitumor, anti-HIV, and cardiovascular (Kappe, 1993) activity. In addition to this, various analogs of pyrimidines have been found to possess antibacterial (Sharma et al, 2004;Prakash et al, 2004;Botta et al, 1992;Cieplik et al, 2015), antifungal (Agarwal et al, 2000;Oliver et al, 2016), antileishmanial (Ram et al, 1992;Alptuzun et al, 2013), anti-inflammatory (Amir et al, 2007;Sondhi et al, 2008), analgesic (Vega et al, 1990; Gupta et al, 2011), anti- hypertensive (Hannah & Stevens, 2003;Rana et al, 2004;Alam et al, 2010), antipyretic (Smith & Kan, 1964;El-Sharkawy et al, 2018), antiviral (Balzarini & McGuigan, 2002;Nasr & Gineinah, 2002), antidiabetic (Lee et al, 2005;Reddy et al, 2019), antiallergic (Juby et al, 1979;Gupta et al, 1995), anticonvulsant (Gupta et al, 1994;Shaquiquzzaman et al, 2012), antioxidant (Krivonogov, et al, 2001;Abu-Hashem et al, 2010, antihistaminic (Prasad & Rahaman, 2008;Rahaman et al, 2009), herbicidal (Nezu et al, 1996;Li et al, 2018), and anticancer activities (Abu-Hashem et al, 2010Xie et al, 2009;Kaldrikyan et al, 2000;Mohamed et al, 2...…”

Design, synthesis, and biological evaluation of thiourea and guanidine derivatives of pyrimidine-6-carboxylate

“…Bignelli reaction, a threecomponent cyclocondensation reaction, is one of the methods described to synthesize dihydropyrimidine derivatives [7]. Further, the dihydropyrimidine moiety has been considered as an important class of heterocyclic compounds exhibiting a variety of potent biological activities such as antiviral [8], antimicrobial [9], antioxidant [10], anti-inflammatory [11], anti-allergic [12], anticancer [13], calcium channel blockers [14], and antidiabetic, etc. [15].…”

Synthesis and antioxidant activity of aminomethylated 6-methyluracil derivatives

“…Continuing our studies of the biological activity of uracil derivatives [4,5], we have investigated the Mannich reaction of uracils with formaldehyde and secondary amines and have studied the antioxidant activity of the resulting compounds.…”