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Mosqueira, Vanessa Carla Furtado; Legrand, Philippe; Morgat, Jean‐Louis; Vert, Michel; Mysiakine, Evgueni; Gref, Ruxandra; Devissaguet, Jean‐Philippe; Barratt, Gillian

doi:10.1023/a:1012248721523

Cited by 258 publications

(96 citation statements)

References 17 publications

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“…However, PLA-PEG NC showed greater efficacy. This result confirms the previously reported long-circulating properties of PLA-PEG NC (24). PLA-PEG NC have already improved the antiprotozoal efficacy of halofantrine by increasing the blood circulation times of this drug (37).…”

Section: Discussionsupporting

confidence: 91%

“…In LYC-PLA-PEG NC formulations, the NC surface is modified by PEG. PEG chains retard the rapid removal of NC from the bloodstream by macrophages, consequently prolonging the drug-associated plasma half-life (24,25,37). Thus, these nanoparticles have the chance to extravasate to tissues infected by T. cruzi, particularly at inflammatory sites (26).…”

Section: Discussionmentioning

confidence: 99%

“…Polymeric NC are formed by an oil droplet surrounded by a polymeric membrane stabilized by surfactants (21) and have been used successfully for the following purposes: to increase the dispersibility of poorly water-soluble drugs, to protect drugs against inactivation (22), to reduce drug toxicity (23), to control drug release (13), and to prolong blood circulation time after intravenous (i.v.) administration (24).…”

mentioning

confidence: 99%

“…Two types of polymeric NC were used: one conventional form that is rapidly cleared from blood circulation by phagocytes of the mononuclear phagocyte system (PCL NC) and the other (PLA-PEG NC) that circulates longer in blood due to its polymeric steric stabilization which reduces uptake by phagocytes (25). Thus, the probability of LYC to target sites of inflammation induced by the presence of the parasite, particularly during the acute phase of infection, is expected to be increased due to increased plasma circulation time of PEG sterically stabilized NC (20,24,25,26).…”

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confidence: 99%

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Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Branquinho

Mosqueira

Oliveira-Silva

et al. 2014

Antimicrob Agents Chemother

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dThe drugs available for Chagas disease treatment are toxic and ineffective. We studied the in vivo activity of a new drug, lychnopholide (LYC). LYC was loaded in nanocapsules (NC), and its effects were compared to free LYC and benznidazole against Trypanosoma cruzi. Infected mice were treated in the acute phase at 2.0 mg/kg/day with free LYC, LYC-poly--caprolactone NC (LYC-PCL), and LYC-poly(lactic acid)-co-polyethylene glycol NC (LYC-PLA-PEG) or at 50 mg/kg/day with benznidazole solution by the intravenous route. Animals infected with the CL strain, treated 24 h after infection for 10 days, evaluated by hemoculture, PCR, and enzyme-linked immunosorbent assay exhibited a 50% parasitological cure when treated with LYC-PCL NC and 100% cure when treated with benznidazole, but 100% of the animals treated during the prepatent period for 20 days with these formulations or LYC-PLA-PEG NC were cured. In animals with the Y strain treated 24 h after infection for 10 days, only mice treated by LYC-PCL NC were cured, but animals treated in the prepatent period for 20 days exhibited 100, 75, and 62.5% cure when treated with LYC-PLA-PEG NC, benznidazole, and LYC-PCL NC, respectively. Free LYC reduced the parasitemia and improved mice survival, but no mice were cured. LYC-loaded NC showed higher cure rates, reduced parasitemia, and increased survival when used in doses 2five times lower than those used for benznidazole. This study confirms that LYC is a potential new treatment for Chagas disease. Furthermore, the long-circulating property of PLA-PEG NC and its ability to improve LYC efficacy showed that this formulation is more effective in reaching the parasite in vivo.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Branquinho

Mosqueira

Oliveira-Silva

et al. 2014

Antimicrob Agents Chemother

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“…Both surface modification and applications of magnetic iron oxide nanoparticles have been reviewed recently (Mosqueira et al 2001;Berry & Curtis 2003;Ueno & Sekino 2006;Lu et al 2007;Xu & Sun 2007;Laurent et al 2008;Sun et al 2008).…”

Section: Applications Outlookmentioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,401

1,092

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Inorganic colloidal nanoparticles are very small, nanoscale objects with inorganic cores that are dispersed in a solvent. Depending on the material they consist of, nanoparticles can possess a number of different properties such as high electron density and strong optical absorption (e.g. metal particles, in particular Au), photoluminescence in the form of fluorescence (semiconductor quantum dots, e.g. CdSe or CdTe) or phosphorescence (doped oxide materials, e.g. Y 2 O 3 ), or magnetic moment (e.g. iron oxide or cobalt nanoparticles). Prerequisite for every possible application is the proper surface functionalization of such nanoparticles, which determines their interaction with the environment. These interactions ultimately affect the colloidal stability of the particles, and may yield to a controlled assembly or to the delivery of nanoparticles to a target, e.g. by appropriate functional molecules on the particle surface. This work aims to review different strategies of surface modification and functionalization of inorganic colloidal nanoparticles with a special focus on the material systems gold and semiconductor nanoparticles, such as CdSe/ZnS. However, the discussed strategies are often of general nature and apply in the same way to nanoparticles of other materials.

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Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

Ahmed¹,

Mora-Huertas²,

Jaafar‐Maalej³

et al. 2013

Drug Delivery Strategies for Poorly Water‐Soluble Drugs

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Abstract: Covalently attached PEG on the surface of NCs substantially can reduce their clearance from the blood compartment and alter their biodistribution.

Cited by 258 publications

References 17 publications

Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

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