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Tv, Shcherbatykh; Ve, Golimbet; Va, Orlova; Vg, Kaleda

doi:10.1023/a:1009031626668

Cited by 5 publications

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References 13 publications

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“…Amplification and identification of allele variants of 5-HTR2A and 5-HTT genes were carried out as described previously [1,3], of GABRA6 gene by 5'-endonuclease analysis. Amplification and identification of allele variants of 5-HTR2A and 5-HTT genes were carried out as described previously [1,3], of GABRA6 gene by 5'-endonuclease analysis.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Associations between 5-HTT, 5-HTR2A, and GABRA6 Gene Polymorphisms and Health-Associated Personality Traits

et al. 2010

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The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neuroticism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.

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Section: Methodsmentioning

confidence: 99%

Analysis of Associations between 5-HTT, 5-HTR2A, and GABRA6 Gene Polymorphisms and Health-Associated Personality Traits

et al. 2010

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Interaction analysis between 5-HTTLPR and TNFA −238/−308 polymorphisms in schizophrenia

et al. 2005

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This study investigated the potential interaction between the polymorphisms of serotonin transporter gene (SLC6A4, a 44 base pair insertion/deletion in the promoter region, 5-HTTLPR) and tumor necrosis factor-alpha gene (TNFA; -238G/A and -308G/A polymorphisms) on the development of schizophrenia, as well as the interaction of the three polymorphisms in relation to symptomatology, family history, onset age and antipsychotic treatment response. Genomic DNA analyses with polymerase chain reaction (PCR) was used for the genotyping. One hundred and fifty-two (152) patients with schizophrenia and 152 normal controls participated in the study. Any associations between the individual polymorphism and schizophrenia were not found. However, marginal association between subjects with both TNFA -238 A allele (genotype AA plus AG) and 5-HTTLPR s allele (ss plus sl) and presence of family history was found (p = 0.023; p = 0.026). The subjects with TNFA -308 AG genotype showed higher change in PANSS total score (p = 0.028). No significant interaction effect between 5-HTTLPR and TNFA -238/-308 polymorphisms either on the development of schizophrenia or on antipsychotics treatment response and psychopathology was found, although a significant interaction effect for subjects carrying TNFA -238 AG and -308 AA genotypes on a positive family history was observed (p = 0.017). These results suggest that the interaction effects between 5-HTTLPR and TNFA -238/-308 polymorphisms gives no significant contribution to the susceptibility to schizophrenia, and is not associated with clinical variables, antipsychotic treatment response and psychopathological features, except for family history of disease, at least in the Korean population.

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No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia

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et al. 2005

Neuroscience Research

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Cited by 5 publications

References 13 publications

Analysis of Associations between 5-HTT, 5-HTR2A, and GABRA6 Gene Polymorphisms and Health-Associated Personality Traits

Analysis of Associations between 5-HTT, 5-HTR2A, and GABRA6 Gene Polymorphisms and Health-Associated Personality Traits

Interaction analysis between 5-HTTLPR and TNFA −238/−308 polymorphisms in schizophrenia

No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia

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