6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

Moon, Minho; Kim, Hyo Geun; Choi, Jin Gyu; Oh, Hyun Sook; Lee, Paula K.J.; Ha, Sang Keun; Kim, Sun Yeou; Park, Yongkon; Huh, Youngbuhm; Oh, Myung Sook

doi:10.1016/j.bbrc.2014.04.121

Cited by 117 publications

(85 citation statements)

References 33 publications

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“…It improves memory by inhibiting the activity of glial cells in animal models of dementia and also by reducing memory corruption. 15 Besides, Ginger decreases activity of NF-κB, 16,17 iNOS, and Cyclooxygenase2 (COX-2).…”

Section: Ginger and Improvement Of The Neurological Degenerative Disementioning

confidence: 99%

Ginger and its Effects on Inflammatory Diseases

Aryaeian¹,

Tavakkoli²

2015

Adv Food Technol Nutr Sci Open J

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Today, Ginger is used as a spice all around the world. In the past, Ginger was consumed for the treatment of various diseases, including osteo-arthritis, neurological diseases, vomiting, asthma, and so on. It seems that Ginger can reduce inflammation in those diseases. We searched the following keywords in PubMed, Google scholar, and Scopus database until 2015: inflammation and Ginger, Ginger and diseases. Clinical trials, animal studies, and human studies were included in the results of this search. Ginger extract with the antioxidant and anti-inflammatory ingredients such as 6 Gingerols, 6-Shogoals, Zhingerol, etc can reduce inflammatory mediators such as inflammatory cytokines and chemokines due to their effects on NF-κB activation, cyclooxygenase 2 reduction and serotonin receptors inhibition. It increases reducing antioxidant enzymes so it can be useful in inflammatory diseases improvement and their complications prevention. In conclusion, Ginger can help in the treatment of inflammatory chronic diseases such as Fatty Liver, Asthma, Cancer and Arthritis through anti-inflammatory, immunoregulatory and antioxidative mechanisms.

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Section: Ginger and Improvement Of The Neurological Degenerative Disementioning

confidence: 99%

Ginger and its Effects on Inflammatory Diseases

Aryaeian¹,

Tavakkoli²

2015

Adv Food Technol Nutr Sci Open J

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“…41 It has also been linked also to memory and cognitive enhancing properties. 42 FTIR spectroscopy is a useful method for obtaining information on the chemical nature of natural product mixture. It detects the vibrational frequencies and intensities of individual functional groups of the components in the mixture with high sensitivity and time resolution and permit quantification of specific classes of dissolved organic matters including aromatic and aliphatic organic compound containing oxygen, nitrogen, and sulfur functional groups.…”

Section: Resultsmentioning

confidence: 99%

GC- MS, FTIR, UV Analysis and in vitro Antioxidant Activity of a Nigeria Poly Herbal Mixture: Pax Herbal Bitters

Elufioye

Mada

2018

FRA

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Objective:The use of herbal products by the majority is primarily based on the belief that herbal drugs are safe, without any side effects, accessible and available at minimal cost. However, there is need for quality assurance of the botanicals in these products in order to meet the demands of product quality and efficacy. In this study, we aimed at identifying the chemical compositions of Pax herbal bitters towards a better understanding of its pharmacological claims. Methods: Pax herbal bitters purchased from licensed pharmacies in Nigeria was extracted separately with n-Hexane, Dichloromethane (DCM) and methanol. DPPH radical scavenging activity, total phenolic and total flavonoid content analysis of the various extracts were carried out. Chemical analysis of the extracts was also done using GC-MS, FTIR and UV. Results: The DPPH radical scavenging antioxidant activity showed highest activity in the DCM extract with an IC 50 of 0.0167 while the total phenolic and total flavonoid content expressed as galic acid equivalents were found to be 20.00±0.23 and 2.55±0.01 for the methanol extract respectively and 5.39+ 0.01 and 2.54+ 0.14 for the DCM extract. The GC-MS, FTIR, and UV-VIS results showed that the herbal preparation contained compounds which may offer great pharmacological values. Some of the identified compounds include Isoborneol (0.61%, antioxidant, neuroprotective), Terpinen-4-ol (4.54%, anti-inflammatory, anti-fungi), 2, 4-Ditertbutylphenol (4.61% antioxidant, antifungi), Caryophyllene (9.33%, anti-inflammatory, anticancer), Isospathulenol (2.14%, immune-inhibitory), shogaol (15.16%, anti-cough, memory enhancer) and p-Heptylacetophenone (9.435%, anti-allergic). Conclusion: This study provides chemical basis for some of the claimed pharmacological actions of Pax herbal bitters.

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“…reversed transgene-associated behavioral deficits and decreased brain parenchymal and cerebral vascular b-amyloid deposits and also hyperforin at 6 µM (Dinamarca et al 2006). Moon et al (2014) proved that the phenylpropanoid, 6-shogaol, at 10 mg/kg b.w. was effective in reducing microgliosis and astrogliosis, ameliorating AbO 1-42 -induced memory impairment and elevating NGF levels, and also pre-and postsynaptic markers.…”

Section: Bioactive Compounds With In Vivo Neuroprotectivementioning

confidence: 99%