6-Methoxy-tetrahydro-β-carboline in the retinae of rabbits and pigs

Melatonin Beyond Its Classical Functions

“…However, in Lingulodinium, the predominant fate of 5-methoxyindole-3-acetaldehyde is that of oxidation by aldehyde dehydrogenase to 5-MIAA, which is released from the cells, does practically not re-enter them from the relatively alkaline seawater and does not exhibit any demonstrable effect in this species [20][21][22]. 5-MT is also the likely source of pinoline found in L. polyedrum, as it is usually the case in other systems, including the mammalian and avian brain, retina and pineal [35][36][37]. Reactions of melatonin with free oxygen radicals, as they occur in any aerobic organism, and which are likely with this indoleamine owing to its remarkably high reactivity to radicals [38][39][40], are also possible in any of the unicells mentioned.…”

LIGHT MICROSCOPIC AUTORADIOGRAPHY OF RAT RETINAE AFTER INTRAVITREAL INJECTION OF [3H]6‐METHOXY‐TETRAHYDRO‐β‐CARBOLINE

“…62. 3 method (Leino et al 1983a). Our group has shown much higher levels of 6-MeO-THBC in the pineal gland (Kari 1981).…”

“…p-carboline derivatives have been identified in many plants and in tissues of man and animals (Airaksinen & Kari 198 la). 6-Methoxy-1,2,3,4-tetrahydro-fi-carboline (6-MeO-THBC) has been shown to occur in the rat brain and adrenals (Barker et al 198 1) although disputed by Faull et al (1982), in the pineal gland of man and fowl (Kari et al 1983) and recently in the retina of some animals (Leino et al 1983a). The biotransformation and distribution of fi-carbolines have received only little attention.…”

Binding of Pinoline on the 5‐Hydroxytryptamine Transporter: Competitive Interaction with [3H] Citalopram

“…Among endogenously found j3-carbolines probably most attention has been given to the pinoline (6-methoxy-1,2,3,4-tetrahydro-P-carboline, 6-MeO-THBC, 5-methoxytryptoline). This compound has been found in pineal and adrenal glands, in retina and in brain in concentrations ranging from 2 ng/g or below that (Barker et al 1981;Langer et al 1986), 0.1-1 pg/g (Leino et al 1983;Kari et al 1983) up to concentration 21 pg/g (Langer et al 1984b). In rat and human blood the concentration of endogenous pinoline has been found below the detection limit, although pinoline has been found in trace amounts in human platelets (Schouten & Bruinvels 1985).…”