1 Experiments were conducted to evaluate the e ects of the novel non-peptide neuropeptide Y Y 1 receptor antagonist, BIBP3226 (N 2 -(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide) on spontaneous, fasting-induced and NPY-induced food intake in rats. In addition to consumption of regular chow, the e ects of BIBP3226 on consumption of highly palatable sweetened mash were monitored in a 1 h test on ®rst exposure and after familiarization with novel food. 2 BIBP3226 (10.0 nmol, i.c.v.) had no e ect on the consumption of regular chow, but reduced signi®cantly the intake of highly palatable diet and the food intake stimulated by fasting (24 h
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