6‐Gingerol, an active pungent component of ginger, inhibits L‐type Ca²⁺ current, contractility, and Ca²⁺ transients in isolated rat ventricular myocytes

Abstract

Ginger has been widely used as a flavor, food, and traditional medicine for centuries. 6‐Gingerol (6‐Gin) is the active components of ginger and offers some beneficial effects on cardiovascular diseases. Here, the effects of 6‐Gin on L‐type Ca 2+ current (I Ca‐L ), contractility, and the Ca 2+ transients of rat cardiomyocytes, were investigated via patch‐clamp technique and the Ion Optix system. The 6‐Gin decreased the I Ca‐L of normal and ischemic ventricular myocytes by 58.17 ± 1.05% and 55.22 ± 1.34%, respectively. 6‐Gin decreased I Ca‐L in a concentration‐dependent manner with a half‐maximal inhibitory concentration (IC 50 ) of 31.25 μmol/L. At 300 μmol/L, 6‐Gin reduced the cell shortening by 48.87 ± 5.44% and the transients by 42.5 ± 9.79%. The results indicate that the molecular mechanisms underlying the cardio‐protective effects of 6‐Gin may because of a decreasing of intracellular Ca 2+ via the inhibition of I Ca‐L and contractility in rat cardiomyocytes.

Therapeutic effects of higenamine combined with [6]‐gingerol on chronic heart failure induced by doxorubicin via ameliorating mitochondrial function

“…6‐gingerol ([6]‐GR), a major bioactive constituent of ginger, is the most abundant and pungent gingerol in ginger. It has many effective pharmacological effects, such as cardiotonic, anti‐angiogenesis, anti‐inflammatory, anti‐cancer, antipyretic and anti‐ageing . Notably, [6]‐GR is a novel angiotensin II receptor (AT1) antagonist and offers some beneficial effects on cardiovascular diseases .…”

[6]‐Gingerol Ameliorates ISO‐Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF‐κB Pathway

“…[3][4][5][6] [6]-gingerol (6-Gin) is one of the primary pungent constituents of ginger and has antipyretic and cardiotonic properties. [7][8][9][10] Its structural formula is shown in Figure 1.…”

“…[28] Thus, the suppression of TLR4/NF-B pathway prevents inflammation. [29][30][31] Our previous study [9] have indicated that the cardio-protective effects of 6-Gin may because of a decreasing of intracellular Ca 2+ via the inhibition of I Ca-L and contractility in rat cardiomyocytes. Herbal drugs, including 6-Gin are becoming more accepted among the public and medical professionals.…”

Zingiberis Rhizoma Recens: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Toxicology

“…These researchers found that FG alleviated memory dysfunction induced by the Aβ 1−42 plaque toxicity and inhibited Aβ 1−42 plaque-induced neuronal cell loss in the CA3 region of the hippocampus. Thus, these studies showed the antiamnesic effects of FG against the Aβ 1−42 plaque toxicity by inhibiting neuronal cell loss and synaptic disturbance, besides suggesting that FG can alleviate AD-like memory dysfunction and neuronal degradation [ 36 ].…”